2022 Publications

  1. Canny, M.D., and M.P. Latham, “LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex,” eLife 11, e69579 (2022). (doi:10.7554/eLife.69579)
  2. Childers, K.C., S.C. Peters, P. Lollar, H.T. Spencer, C.B. Doering, and P.C. Spiegel, “SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa,” Blood Advances 6(11), 3240-3254 (2022). (doi:10.1182/bloodadvances.2021005874)
  3. Ehm, T., J. Philipp, M. Barkey, M. Ober, A.T. Brinkop, D. Simml, M. von Westphalen, B. Nickel, R. Beck, and J.O. Rädler, “3D-printed SAXS chamber for controlled in situ dialysis and optical characterization,” Journal of Synchrotron Radiation 29(4), 1014-1019 (2022). (doi:10.1107/S1600577522005136)
  4. Lyons, N.S., A.N. Bogner, J.J. Tanner, and P. Sobrado, “Kinetic and Structural Characterization of a Flavin-Dependent Putrescine N-Hydroxylase from Acinetobacter baumannii,” Biochemistry 61(22), 2607-2620 (2022). (doi:10.1021/acs.biochem.2c00493)
  5. Pham, V.V., M. Gao, J.L. Meagher, J.L. Smith, and V.M. D’Souza, “A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA,” Communications Biology 5(1), 819 (2022). (doi:10.1038/s42003-022-03734-w)
  6. Rosenberg, D.J., G.L. Hura, and M. Hammel, “Size exclusion chromatography coupled small angle X-ray scattering with tandem multiangle light scattering at the SIBYLS beamline,” Methods in Enzymology 677, 191-219 (2022). (doi:10.1016/bs.mie.2022.08.031)
  7. McCallum M, Czudnochowski N, Rosen LE, Zepeda SK, Bowen JE, Walls AC, Hauser K, Joshi A, Stewart C, Dillen JR, Powell AE, Croll TI, Nix J, Virgin HW, Corti D, Snell G, Veesler D. Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. Science. 2022 Feb 25;375(6583):864-868. doi: 10.1126/science.abn8652. Epub 2022 Jan 25. PMID: 35076256
  8. Dauparas J, Anishchenko I, Bennett N, Bai H, Ragotte RJ, Milles LF, Wicky BIM, Courbet A, de Haas RJ, Bethel N, Leung PJY, Huddy TF, Pellock S, Tischer D, Chan F, Koepnick B, Nguyen H, Kang A, Sankaran B, Bera AK, King NP, Baker D. Robust deep learning-based protein sequence design using ProteinMPNN. Science. 2022 Oct 7;378(6615):49-56. doi: 10.1126/science.add2187. Epub 2022 Sep 15. PMID: 36108050
  9. Zhang Z, Rohweder PJ, Ongpipattanakul C, Basu K, Bohn MF, Dugan EJ, Steri V, Hann B, Shokat KM, Craik CS. A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy. Cancer Cell. 2022 Sep 12;40(9):1060-1069.e7. doi: 10.1016/j.ccell.2022.07.005. PMID: 36099883
  10. Knox HL, Booker SJ. Structural characterization of cobalamin-dependent radical S-adenosylmethionine methylases. Methods Enzymol. 2022;669:3-27. doi: 10.1016/bs.mie.2021.12.013. Epub 2022 Jan 28. PMID: 35644177
  11. Ralston CY, Kerfeld CA. Integrated Structural Studies for Elucidating Carotenoid-Protein Interactions.  Adv Exp Med Biol. 2022;1371:1-10. doi: 10.1007/5584_2020_615. PMID: 33963527
  12. Schriber EA, Paley DW, Bolotovsky R, Rosenberg DJ, Sierra RG, Aquila A, Mendez D, Poitevin F, Blaschke JP, Bhowmick A, Kelly RP, Hunter M, Hayes B, Popple DC, Yeung M, Pareja-Rivera C, Lisova S, Tono K, Sugahara M, Owada S, Kuykendall T, Yao K, Schuck PJ, Solis-Ibarra D, Sauter NK, Brewster AS, Hohman JN. Chemical crystallography by serial femtosecond X-ray diffraction.Nature. 2022 Jan;601(7893):360-365. doi: 10.1038/s41586-021-04218-3. Epub 2022 Jan 19. PMID: 35046599
  13. Gorelik A, Illes K, Bui KH, Nagar B. Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.  Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203518119. doi: 10.1073/pnas.2203518119. Epub 2022 Aug 8. PMID: 35939698
  14. Xu Z, Khan S, Schnicker NJ, Baker S. Pentameric assembly of the Kv2.1 tetramerization domain.  Acta Crystallogr D Struct Biol. 2022 Jun 1;78(Pt 6):792-802. doi: 10.1107/S205979832200568X. Epub 2022 May 30. PMID: 35647925
  15. Courbet A, Hansen J, Hsia Y, Bethel N, Park YJ, Xu C, Moyer A, Boyken SE, Ueda G, Nattermann U, Nagarajan D, Silva DA, Sheffler W, Quispe J, Nord A, King N, Bradley P, Veesler D, Kollman J, Baker D. Computational design of mechanically coupled axle-rotor protein assemblies. Science. 2022 Apr 22;376(6591):383-390. doi: 10.1126/science.abm1183. Epub 2022 Apr 21. PMID: 35446645
  16. Bauman KD, Shende VV, Chen PY, Trivella DBB, Gulder TAM, Vellalath S, Romo D, Moore BS. Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead. Nat Chem Biol. 2022 May;18(5):538-546. doi: 10.1038/s41589-022-00993-w. Epub 2022 Mar 21. PMID: 35314816
  17. Bauman KD, Shende VV, Chen PY, Trivella DBB, Gulder TAM, Vellalath S, Romo D, Moore BS. Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead. Nat Chem Biol. 2022 May;18(5):538-546. doi: 10.1038/s41589-022-00993-w. Epub 2022 Mar 21. PMID: 35314816
  18. Neugebauer ME, Kissman EN, Marchand JA, Pelton JG, Sambold NA, Millar DC, Chang MCY. Reaction pathway engineering converts a radical hydroxylase into a halogenase. Nat Chem Biol. 2022 Feb;18(2):171-179. doi: 10.1038/s41589-021-00944-x. Epub 2021 Dec 22. PMID: 34937913
  19. Liu AK, Pereira JH, Kehl AJ, Rosenberg DJ, Orr DJ, Chu SKS, Banda DM, Hammel M, Adams PD, Siegel JB, Shih PM. Structural plasticity enables evolution and innovation of RuBisCO assemblies. Sci Adv. 2022 Aug 26;8(34):eadc9440. doi: 10.1126/sciadv.adc9440. Epub 2022 Aug 26. PMID: 36026446
  20. Kakkis A, Golub E, Choi TS, Tezcan FA. Redox- and metal-directed structural diversification in designed metalloprotein assemblies. Chem Commun (Camb). 2022 Jun 16;58(49):6958-6961. doi: 10.1039/d2cc02440c. PMID: 35642584
  21. Cofsky JC, Knott GJ, Gee CL, Doudna JA. Crystal structure of an RNA/DNA strand exchange junction. PLoS One. 2022 Apr 18;17(4):e0263547. doi: 10.1371/journal.pone.0263547. eCollection 2022. PMID: 35436289
  22. Lin JS, Bekale LA, Molchanova N, Nielsen JE, Wright M, Bacacao B, Diamond G, Jenssen H, Santa Maria PL, Barron AE. Anti-persister and Anti-biofilm Activity of Self-Assembled Antimicrobial Peptoid Ellipsoidal Micelles. ACS Infect Dis. 2022 Sep 9;8(9):1823-1830. doi: 10.1021/acsinfecdis.2c00288. Epub 2022 Aug 26. PMID: 36018039
  23. Hulce KR, Jaishankar P, Lee GM, Bohn MF, Connelly EJ, Wucherer K, Ongpipattanakul C, Volk RF, Chuo SW, Arkin MR, Renslo AR, Craik CS. Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine. Cell Chem Biol. 2022 May 19;29(5):785-798.e19. doi: 10.1016/j.chembiol.2022.03.007. Epub 2022 Mar 31. PMID: 35364007
  24. Yachnin BJ, Azouz LR, White RE 3rd, Minetti CASA, Remeta DP, Tan VM, Drake JM, Khare SD. Massively parallel, computationally guided design of a proenzyme. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2116097119. doi: 10.1073/pnas.2116097119. Epub 2022 Apr 4. PMID: 35377786
  25. Clanor PB, Buchholz CN, Hayes JE, Friedman MA, White AM, Enke RA, Berndsen CE. Proteins. Structural and functional analysis of the human cone-rod homeobox transcription factor 2022 Aug;90(8):1584-1593. doi: 10.1002/prot.26332. Epub 2022 Mar 23. PMID: 35255174
  26. Knox HL, Sinner EK, Townsend CA, Boal AK, Booker SJ. Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis. Nature. 2022 Feb;602(7896):343-348. doi: 10.1038/s41586-021-04392-4. Epub 2022 Feb 2. PMID: 35110734
  27. Choi TS, Tezcan FA. Overcoming universal restrictions on metal selectivity by protein design. Nature. 2022 Mar;603(7901):522-527. doi: 10.1038/s41586-022-04469-8. Epub 2022 Mar 2. PMID: 35236987
  28. Simmons CR, MacCulloch T, Krepl M, Matthies M, Buchberger A, Crawford I, Šponer J, Šulc P, Stephanopoulos N, Yan H. The influence of Holliday junction sequence and dynamics on DNA crystal self-assembly. Nat Commun. 2022 Jun 3;13(1):3112. doi: 10.1038/s41467-022-30779-6. PMID: 35662248
  29. Lloyd CT, Iwig DF, Wang B, Cossu M, Metcalf WW, Boal AK, Booker SJ. Discovery, structure and mechanism of a tetraether lipid synthase. Nature. 2022 Sep;609(7925):197-203. doi: 10.1038/s41586-022-05120-2. Epub 2022 Jul 26. PMID: 35882349
  30. Bratkowski M, Burdett TC, Danao J, Wang X, Mathur P, Gu W, Beckstead JA, Talreja S, Yang YS, Danko G, Park JH, Walton M, Brown SP, Tegley CM, Joseph PRB, Reynolds CH, Sambashivan S. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Neuron. 2022 Nov 16;110(22):3711-3726.e16. doi: 10.1016/j.neuron.2022.08.017. Epub 2022 Sep 9. PMID: 36087583
  31. Travis BA, Peck JV, Salinas R, Dopkins B, Lent N, Nguyen VD, Borgnia MJ, Brennan RG, Schumacher MA. Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun. 2022 Jul 1;13(1):3793. doi: 10.1038/s41467-022-31573-0. PMID: 35778410
  32. Huang Z, Liu H, Nix J, Xu R, Knoverek CR, Bowman GR, Amarasinghe GK, Sibley LD. The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nat Commun. 2022 Jul 13;13(1):4047. doi: 10.1038/s41467-022-31720-7. PMID: 35831295
  33. Rosenberg DJ, Syed A, Tainer JA, Hura GL. Monitoring Nuclease Activity by X-Ray Scattering Interferometry Using Gold Nanoparticle-Conjugated DNA. Methods Mol Biol. 2022;2444:183-205. doi: 10.1007/978-1-0716-2063-2_12. PMID: 35290639
  34. Hicks DR, Kennedy MA, Thompson KA, DeWitt M, Coventry B, Kang A, Bera AK, Brunette TJ, Sankaran B, Stoddard B, Baker D. De novo design of protein homodimers containing tunable symmetric protein pockets. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2113400119. doi: 10.1073/pnas.2113400119. Epub 2022 Jul 21. PMID: 35862457
  35. van Schooten J, Farokhi E, Schorcht A, van den Kerkhof TLGM, Gao H, van der Woude P, Burger JA, Meesters TGR, Bijl T, Ghalaiyini R, Turner HL, Dorning J, van Schaik BDC, van Kampen AHC, Labranche CC, Stanfield RL, Sok D, Montefiori DC, Burton DR, Seaman MS, Ozorowski G, Wilson IA, Sanders RW, Ward AB, van Gils MJ. Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein. Nat Commun. 2022 Aug 3;13(1):4515. doi: 10.1038/s41467-022-32208-0. PMID: 35922441
  36. Sharma R, Kim JJ, Qin L, Henning P, Akimoto M, VanSchouwen B, Kaur G, Sankaran B, MacKenzie KR, Melacini G, Casteel DE, Herberg FW, Kim C. An auto-inhibited state of protein kinase G and implications for selective activation. Elife. 2022 Aug 5;11:e79530. doi: 10.7554/eLife.79530. PMID: 35929723
  37. McGinnis RJ, Brambley CA, Stamey B, Green WC, Gragg KN, Cafferty ER, Terwilliger TC, Hammel M, Hollis TJ, Miller JM, Gainey MD, Wallen JR. A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence. Nat Commun. 2022 Jul 14;13(1):4105. doi: 10.1038/s41467-022-31678-6. PMID: 35835745
  38. Hu L, Salmen W, Sankaran B, Lasanajak Y, Smith DF, Crawford SE, Estes MK, Prasad BVV. Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography. Commun Biol. 2022 May 5;5(1):419. doi: 10.1038/s42003-022-03357-1. PMID: 35513489
  39. Rosi M, Russell B, Kristensen LG, Farquhar ER, Jain R, Abel D, Sullivan M, Costello SM, Dominguez-Martin MA, Chen Y, Marqusee S, Petzold CJ, Kerfeld CA, DePonte DP, Farahmand F, Gupta S, Ralston CY. An automated liquid jet for fluorescence dosimetry and microsecond radiolytic labeling of proteins. Commun Biol. 2022 Aug 25;5(1):866. doi: 10.1038/s42003-022-03775-1. PMID: 36008591
  40. Chen PY, Adak S, Chekan JR, Liscombe DK, Miyanaga A, Bernhardt P, Diethelm S, Fielding EN, George JH, Miles ZD, Murray LAM, Steele TS, Winter JM, Noel JP, Moore BS. Biochemistry. Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. 2022 Sep 6;61(17):1844-1852. doi: 10.1021/acs.biochem.2c00338. Epub 2022 Aug 19. PMID: 35985031
  41. Gupta S, Raskatov JA, Ralston CY. A Hybrid Structural Method for Investigating Low Molecular Weight Oligomeric Structures of Amyloid Beta. Chembiochem. 2022 Dec 5;23(23):e202200333. doi: 10.1002/cbic.202200333. Epub 2022 Sep 13. PMID: 35980391
  42. Atanasio A, Franklin MC, Kamat V, Hernandez AR, Badithe A, Ben LH, Jones J, Bautista J, Yancopoulos GD, Olson W, Murphy AJ, Sleeman MA, Orengo JM. Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response.  J Allergy Clin Immunol. 2022 Jan;149(1):200-211. doi: 10.1016/j.jaci.2021.05.038. Epub 2021 Jun 11. PMID: 34126155
  43. Guercio AM, Torabi S, Cornu D, Dalmais M, Bendahmane A, Le Signor C, Pillot JP, Le Bris P, Boyer FD, Rameau C, Gutjahr C, de Saint Germain A, Shabek N. Structural and functional analyses explain Pea KAI2 receptor diversity and reveal stereoselective catalysis during signal perception. Commun Biol. 2022 Feb 11;5(1):126. doi: 10.1038/s42003-022-03085-6. PMID: 35149763
  44. Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA. Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers. J Clin Invest. 2022 Feb 15;132(4):e154604. doi: 10.1172/JCI154604. PMID: 35166238
  45. Gozzi K, Salinas R, Nguyen VD, Laub MT, Schumacher MA. ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD. Genes Dev. 2022 May 1;36(9-10):618-633. doi: 10.1101/gad.349541.122. Epub 2022 May 26. PMID: 35618312
  46. Ohmer CJ, Dasgupta M, Patwardhan A, Bogacz I, Kaminsky C, Doyle MD, Chen PY, Keable SM, Makita H, Simon PS, Massad R, Fransson T, Chatterjee R, Bhowmick A, Paley DW, Moriarty NW, Brewster AS, Gee LB, Alonso-Mori R, Moss F, Fuller FD, Batyuk A, Sauter NK, Bergmann U, Drennan CL, Yachandra VK, Yano J, Kern JF, Ragsdale SW. XFEL serial crystallography reveals the room temperature structure of methyl-coenzyme M reductase. J Inorg Biochem. 2022 May;230:111768. doi: 10.1016/j.jinorgbio.2022.111768. Epub 2022 Feb 17. PMID: 35202981
  47. Mahoney BJ, Takayesu A, Zhou A, Cascio D, Clubb RT. The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing. Proteins. 2022 Jul;90(7):1457-1467. doi: 10.1002/prot.26326. Epub 2022 Feb 28. PMID: 35194841
  48. Nielsen JE, Alford MA, Yung DBY, Molchanova N, Fortkort JA, Lin JS, Diamond G, Hancock REW, Jenssen H, Pletzer D, Lund R, Barron AE. Self-Assembly of Antimicrobial Peptoids Impacts Their Biological Effects on ESKAPE Bacterial Pathogens. ACS Infect Dis. 2022 Mar 11;8(3):533-545. doi: 10.1021/acsinfecdis.1c00536. Epub 2022 Feb 17. PMID: 35175731
  49. Ngo VA, Queralt-Martín M, Khan F, Bergdoll L, Abramson J, Bezrukov SM, Rostovtseva TK, Hoogerheide DP, Noskov SY. The Single Residue K12 Governs the Exceptional Voltage Sensitivity of Mitochondrial Voltage-Dependent Anion Channel Gating. J Am Chem Soc. 2022 Aug 17;144(32):14564-14577. doi: 10.1021/jacs.2c03316. Epub 2022 Aug 4. PMID: 35925797
  50. Wagschal K, Chan VJ, Pereira JH, Zwart PH, Sankaran B. Chromohalobacter salixigens Uronate Dehydrogenase: Directed Evolution for Improved Thermal Stability and Mutant CsUDH-inc X-ray Crystal Structure. Process Biochem. 2022 Mar;114:185-192. doi: 10.1016/j.procbio.2020.02.013. Epub 2020 Feb 14. PMID: 35462854
  51. Cantara WA, Pathirage C, Hatterschide J, Olson ED, Musier-Forsyth K. Phosphomimetic S207D Lysyl-tRNA Synthetase Binds HIV-1 5’UTR in an Open Conformation and Increases RNA Dynamics. Viruses. 2022 Jul 16;14(7):1556. doi: 10.3390/v14071556. PMID: 35891536
  52. Nuñez Castrejon AM, O’Rourke SM, Kauvar LM, DuBois RM. Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens.  J Virol. 2022 Apr 13;96(7):e0220121. doi: 10.1128/jvi.02201-21. Epub 2022 Mar 10. PMID: 35266806
  53. Selyutina A, Simons LM, Kirby KA, Bulnes-Ramos A, Hu P, Sarafianos SG, Hultquist JF, Diaz-Griffero F. TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection. Viruses. 2022 Feb 10;14(2):363. doi: 10.3390/v14020363. PMID: 35215956
  54. Lee J, Kenward C, Worrall LJ, Vuckovic M, Gentile F, Ton AT, Ng M, Cherkasov A, Strynadka NCJ, Paetzel M. X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nat Commun. 2022 Sep 3;13(1):5196. doi: 10.1038/s41467-022-32854-4. PMID: 36057636
  55. Kim M, Kim HS, D’Souza A, Gallagher K, Jeong E, Topolska-Wós A, Ogorodnik Le Meur K, Tsai CL, Tsai MS, Kee M, Tainer JA, Yeo JE, Chazin WJ, Schärer OD. Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2207408119. doi: 10.1073/pnas.2207408119. Epub 2022 Aug 15. PMID: 35969784
  56. Wang LT, Hurlburt NK, Schön A, Flynn BJ, Flores-Garcia Y, Pereira LS, Kiyuka PK, Dillon M, Bonilla B, Zavala F, Idris AH, Francica JR, Pancera M, Seder RA. The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria. Cell Rep. 2022 Feb 15;38(7):110367. doi: 10.1016/j.celrep.2022.110367. PMID: 35172158
  57. Correy GJ, Kneller DW, Phillips G, Pant S, Russi S, Cohen AE, Meigs G, Holton JM, Gahbauer S, Thompson MC, Ashworth A, Coates L, Kovalevsky A, Meilleur F, Fraser JS. The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature. bioRxiv. 2022 Feb 9:2022.02.07.479477. doi: 10.1101/2022.02.07.479477. Preprint. PMID: 35169801
  58. Azimova D, Herrera N, Duvenage L, Voorhies M, Rodriguez RA, English BC, Hoving JC, Rosenberg O, Sil A. Cbp1, a fungal virulence factor under positive selection, forms an effector complex that drives macrophage lysis. PLoS Pathog. 2022 Jun 22;18(6):e1010417. doi: 10.1371/journal.ppat.1010417. eCollection 2022 Jun. PMID: 35731824
  59. Raeeszadeh-Sarmazdeh M, Coban M, Mahajan S, Hockla A, Sankaran B, Downey GP, Radisky DC, Radisky ES. Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.J Biol Chem. 2022 Mar;298(3):101654. doi: 10.1016/j.jbc.2022.101654. Epub 2022 Jan 29. PMID: 35101440
  60. Canny MD, Latham MP. LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex. Elife. 2022 Jan 27;11:e69579. doi: 10.7554/eLife.69579. PMID: 35084331
  61. Ravenburg CM, Riney MB, Monroe JD, Berndsen CE. Acta Crystallogr D The BAM7 gene in Zea mays encodes a protein with similar structural and catalytic properties to Arabidopsis BAM2. Struct Biol. 2022 May 1;78(Pt 5):560-570. doi: 10.1107/S2059798322002169. Epub 2022 Apr 8. PMID: 35503205
  62. Sestok AE, Brown JB, Obi JO, O’Sullivan SM, Garcin ED, Deredge DJ, Smith AT. A fusion of the Bacteroides fragilis ferrous iron import proteins reveals a role for FeoA in stabilizing GTP-bound FeoB. J Biol Chem. 2022 Apr;298(4):101808. doi: 10.1016/j.jbc.2022.101808. Epub 2022 Mar 8. PMID: 35271852
  63. Luyten YA, Hausman DE, Young JC, Doyle LA, Higashi KM, Ubilla-Rodriguez NC, Lambert AR, Arroyo CS, Forsberg KJ, Morgan RD, Stoddard BL, Kaiser BK. Identification and characterization of the WYL BrxR protein and its gene as separable regulatory elements of a BREX phage restriction system. Nucleic Acids Res. 2022 May 20;50(9):5171-5190. doi: 10.1093/nar/gkac311. PMID: 35511079
  64. Baughman HER, Narang D, Chen W, Villagrán Suárez AC, Lee J, Bachochin MJ, Gunther TR, Wolynes PG, Komives EA. An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA. J Biol Chem. 2022 Sep;298(9):102349. doi: 10.1016/j.jbc.2022.102349. Epub 2022 Aug 5. PMID: 35934050
  65. Dauparas J, I Anishchenko, N Bennett, H Bai, R J Ragotte, L F Milles, B I M Wicky, A Courbet, R J de Haas, N Bethel, P J Y Leung, T F Huddy, S Pellock, D Tischer, F Chan, B Koepnick, H Nguyen, A Kang, B Sankaran, A K Bera, N P King, D Baker. Robust deep learning-based protein sequence design using Protein. Science. 2022 Oct 7;378(6615):49-56. doi: 10.1126/science.add2187. Epub 2022 Sep 15 PMID: 36108050
  66. Yuying Ma, Kai S Yang, Zhi Zachary Geng, Yugendar R Alugubelli, Namir Shaabani, Erol C Vatansever, Xinyu R Ma, Chia-Chuan Cho, Kaustav Khatua, Jing Xiao, Lauren R Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu. A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals. Eur J Med Chem. 2022 Oct 5;240:114570. doi: 10.1016/j.ejmech.2022.114570. Epub 2022 Jun 27.
  67. Venkadesh Sarkarai Nadar, Palani Kandavelu, Banumathi Sankaran, Barry P Rosen, Masafumi Yoshinaga. The ArsI C-As lyase: Elucidating the catalytic mechanism of degradation of organoarsenicals.2022 Jul;232:111836. doi: 10.1016/j.jinorgbio.2022.111836. Epub 2022 Apr 20.
  68. Stokes R, Kohlbrand A.J., Seo H., Sankaran B., Karges J., Cohen S.M., Carboxylic Acid Isostere Derivatives of Hydrozypyridinones as Core Scaffolds for Infuenza Endonuclease Inhibitors. ACS Med. Chem. Lett. Dec 9, 2022. https://doi.org/10.1021/acsmedchemlett.2c00434
  69. Schumacher MA, Wörmann ME, Henderson M, Salinas R, Latoscha A, Al-Bassam MM, Singh KS, Barclay E, Gunka K, Tschowri N. Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP. Nat Commun. 2022 Oct 3;13(1):5834. doi: 10.1038/s41467-022-33537-w. PMID: 36192422
  70. Delgado-Cunningham K, López T, Khatib F, Arias CF, DuBois RM. Structure of the divergent human astrovirus MLB capsid spike. Structure. 2022 Dec 1;30(12):1573-1581.e3. doi: 10.1016/j.str.2022.10.010. Epub 2022 Nov 22. PMID: 36417907
  71. Vitali J, Nix JC, Newman HE, Colaneri MJ. Crystal structure of Methanococcus jannaschii dihydroorotase. Proteins. 2023 Jan;91(1):91-98. doi: 10.1002/prot.26412. Epub 2022 Aug 24. PMID: 35978488
  72. Hanan EJ, Braun MG, Heald RA, MacLeod C, Chan C, Clausen S, Edgar KA, Eigenbrot C, Elliott R, Endres N, Friedman LS, Gogol E, Gu XH, Thibodeau RH, Jackson PS, Kiefer JR, Knight JD, Nannini M, Narukulla R, Pace A, Pang J, Purkey HE, Salphati L, Sampath D, Schmidt S, Sideris S, Song K, Sujatha-Bhaskar S, Ultsch M, Wallweber H, Xin J, Yeap S, Young A, Zhong Y, Staben ST. Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα. J Med Chem. 2022 Dec 22;65(24):16589-16621. doi: 10.1021/acs.jmedchem.2c01422. Epub 2022 Dec 1. PMID: 36455032
  73. Lyons NS, Bogner AN, Tanner JJ, Sobrado P. Kinetic and Structural Characterization of a Flavin-Dependent Putrescine N-Hydroxylase from Acinetobacter baumannii. Biochemistry. 2022 Nov 15;61(22):2607-2620. doi: 10.1021/acs.biochem.2c00493. Epub 2022 Oct 31. PMID: 36314559
  74. Shuo Lu, Liya Hu, Hanfeng Lin, Allison Judge, Paola Rivera, Murugesan Palaniappan, Banumathi Sankaran, Jin Wang, B V Venkataram Prasad, Timothy Palzkill. An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes. Nat Commun. 2022 Nov 7;13(1):6726. doi: 10.1038/s41467-022-34564-3.
  75. Stokes R, Kohlbrand A.J., Seo H., Sankaran B., Karges J., Cohen S.M., Carboxylic Acid Isostere Derivatives of Hydrozypyridinones as Core Scaffolds for Infuenza Endonuclease Inhibitors. ACS Med. Chem. Lett. Dec 9, 2022. https://doi.org/10.1021/acsmedchemlett.2c00434

© 2024 ALS-ENABLE. Built using WordPress and Mesmerize Theme.