{"id":3858,"date":"2026-10-07T13:00:31","date_gmt":"2026-10-07T20:00:31","guid":{"rendered":"https:\/\/als-enable.lbl.gov\/wordpress\/?page_id=3858"},"modified":"2026-10-07T13:00:32","modified_gmt":"2026-10-07T20:00:32","slug":"als-enable-publications-2024","status":"publish","type":"page","link":"https:\/\/als-enable.lbl.gov\/wordpress\/als-enable-publications-2024\/","title":{"rendered":"ALS-ENABLE Publications: 2024"},"content":{"rendered":"\n

177 publications from all four TOCs, listed in order from TOC1 \u2013 TOC4.<\/p>\n\n\n\n

TOC1 \u2014 Rapid Response Crystallography (124)<\/h2>\n\n\n\n
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  1. Victoria Angela Maola, Eric Yik, Mohammad Hajjar, Joy Lee. Directed evolution of a highly efficient TNA polymerase achieved by homologous recombination. Nature Catalysis. PMID not assigned; doi: 10.1038\/s41929-024-01233-1. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  2. Dai J, Izadi S, Zarzar J, Wu P, Oh A, Carter PJ. Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG(1) antibody. MAbs. 2024 Jan-Dec;16(1):2304282. doi: 10.1080\/19420862.2024.2304282. PubMed PMID: 38269489; PubMed Central PMCID: PMC10813588. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  3. Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, et al. Blueprinting extendable nanomaterials with standardized protein blocks. Nature. 2024;627(8005):898 – -904. PMID: 38480887. PMCID: PMC10972742. [also TOC2]<\/strong> method MX \u00b7 beamline 8.2.1 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  4. Liang WC, Xi H, Sun D, D’Ascenzo L, Zarzar J, Stephens N, et al. Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. MAbs. 2024 Jan-Dec;16(1):2309685. doi: 10.1080\/19420862.2024.2309685. PubMed PMID: 38356181; PubMed Central PMCID: PMC10877986. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  5. McLaughlin K, Schwartz L, Norman J, Hasan S, Sankaran B. Abstract 2165 Investigating a Novel Carbohydrate Deacetylase Involved in Bacteroides Capsular Polysaccharide Biosynthesis. Journal of Biological Chemistry. 2024;300(3). method MX \u00b7 beamline 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  6. Nadar VS, Galv\u00e1n AE, Suzol SH, Howlader AH, Chen J, Dheeman DS, Yoshinaga-Sakurai K, Radhakrishnan M, Kandavelu P, Sankaran B, et al. Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a potent broad-spectrum antibiotic. In: Arsenic in the Environment: Bridging Science to Practice for Sustainable Development As2021. CRC Press; 2024. p. 11–12. method MX<\/em> beamline 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  7. Reddi R, Chatterjee S, Matulef K, Gustafson A, Gao L, Valiyaveetil FI. A facile approach for incorporating tyrosine esters to probe ion-binding sites and backbone hydrogen bonds. J Biol Chem. 2024 Jan;300(1):105517. doi: 10.1016\/j.jbc.2023.105517. Epub 2023 Nov 30. PMID: 38042487; PMCID: PMC10790091. method MX \u00b7 beamline 4.2.2<\/em><\/li>\n\n\n\n
  8. Sun Z, Lin H, Hu L, Neetu N, Sankaran B, Wang J, Prasad BVV, Palzkill T. Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J Biol Chem. 2024 Jan;300(1):105493. doi: 10.1016\/j.jbc.2023.105493. Epub 2023 Nov 23. PMID: 38000656; PMCID: PMC10716778. BCSB, TOC1. method MX \u00b7 beamline 8.2.1, 5.0.3 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  9. Yirmiya E, Leavitt A, Lu A, Ragucci AE, Avraham C, Osterman I, et al. Phages overcome bacterial immunity via diverse anti-defence proteins. Nature. 2024 Jan;625(7994):352-359. doi: 10.1038\/s41586-023-06869-w. PubMed PMID: 37992756. method MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  10. Lin Q, Dai S, Qu L, Lin H, Guo M, Wei H, et al. Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R. Commun Chem. 2024 Jan 3;7(1):3. doi: 10.1038\/s42004-023-01084-0. PubMed PMID: 38172256; PubMed Central PMCID: PMC10764862. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  11. Vogel BA, Blount JM, Kodama HM, Goodwin-Rice NJ, Andaluz DJ, Jackson SN, et al. A unique binding mode of P1′ Leu-containing target sequences for Streptococcus pyogenes sortase A results in alternative cleavage. RSC Chem Biol. 2024 Jan 3;5(1):30-40. doi: 10.1039\/d3cb00129f. PubMed PMID: 38179192; PubMed Central PMCID: PMC10763551. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  12. Vernon TN, Terrell JR, Albrecht AV, Germann MW, Wilson WD, Poon GMK. Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors. Structure. 2024 Jan 4;32(1):83-96.e4. doi: 10.1016\/j.str.2023.11.003. PubMed PMID: 38042148; PubMed Central PMCID: PMC12924625. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  13. Sun X, Ferguson JA, Leach BI, Stanfield RL, Dyson HJ, Wright PE. Probing the Dissociation Pathway of a Kinetically Labile Transthyretin Mutant. J Am Chem Soc. 2024 Jan 10;146(1):532-542. doi: 10.1021\/jacs.3c10083. PubMed PMID: 38134439; PubMed Central PMCID: PMC10926950. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  14. Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, et al. Exploiting the Carboxylate-Binding Pocket of \u03b2-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J Med Chem. 2024 Jan 11;67(1):620-642. doi: 10.1021\/acs.jmedchem.3c01834. PubMed PMID: 38117688; PubMed Central PMCID: PMC11489902. method MX \u00b7 beamline 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  15. Mao L, Shaabani N, Zhang X, Jin C, Xu W, Argent C, et al. Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19. Med. 2024 Jan 12;5(1):42-61.e23. doi: 10.1016\/j.medj.2023.12.004. PubMed PMID: 38181791. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  16. Ruttenberg SM, Kreutzer AG, Truex NL, Nowick JS. \u03b2-Hairpin Alignment Alters Oligomer Formation in A\u03b2-Derived Peptides. Biochemistry. 2024 Jan 16;63(2):212-218. doi: 10.1021\/acs.biochem.3c00526. PMID: 38163326; PMCID: PMC10795187. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  17. Chen A, Re RN, Davis TD, Tran K, Moriuchi YW, Wu S, et al. Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes. J Am Chem Soc. 2024 Jan 17;146(2):1388-1395. doi: 10.1021\/jacs.3c10181. PubMed PMID: 38176024; PubMed Central PMCID: PMC12332981. method MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  18. Liu C, Powell MM, Rao G, Britt RD, Rittle J. “Bioinformatic Discovery of a Cambialistic Monooxygenase.” Journal of the American Chemical Society 2024 Jan 24 ;146(3):1783-1788. TOC1. PMID: 38198693; PMCID: PMC10811679. method MX \u00b7 ALS Enable beamline<\/em><\/li>\n\n\n\n
  19. Sumida KH, N\u00fa\u00f1ez-Franco R, Kalvet I, Pellock SJ, Wicky BIM, Milles LF, et al. Improving Protein Expression, Stability, and Function with ProteinMPNN. J Am Chem Soc. 2024 Jan 24;146(3):2054-2061. doi: 10.1021\/jacs.3c10941. PubMed PMID: 38194293; PubMed Central PMCID: PMC10811672. beamline<\/em> \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  20. Ghosh A, Delgado-Cunningham K, L\u00f3pez T, Green K, Arias CF, DuBois RM. “Structure and antigenicity of the divergent human astrovirus VA1 capsid spike.” PLoS pathogens 2024 Feb ;20(2):e1012028. PMID: 38416796. PMCID: PMC10950212. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  21. Hung LW, Terwilliger TC, Waldo GS, Nguyen HB. Engineering highly stable variants of Corynactis californica green fluorescent proteins. Protein Sci. 2024 Feb;33(2):e4886. doi: 10.1002\/pro.4886. PMID: 38151801; PMCID: PMC10804665. BCSB, TOC1. method MX \u00b7 beamline 5.0.1, 5.0.2<\/em><\/li>\n\n\n\n
  22. Mason JW, Chow YT, Hudson L, Tutter A, Michaud G, Westphal MV, et al. DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nat Chem Biol. 2024 Feb;20(2):170-179. doi: 10.1038\/s41589-023-01458-4. PubMed PMID: 37919549; PubMed Central PMCID: PMC10917151. method<\/em> MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  23. Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N. Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Sci Adv. 2024 Feb2;10(5):eadg7887. doi: 10.1126\/sciadv.adg7887. Epub 2024 Jan 31. PMID: 38295166; PMCID: PMC10830117. method MX \u00b7 beamline 8.2.1 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  24. Alysia J Kohlbrand, Ryjul W Stokes, Banumathi Sankaran, Seth M Cohen Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants. Biochemistry. 2024 Feb 6;63(3):264- 272. doi: 10.1021\/acs.biochem.3c00536. Epub 2024 Jan 8. PMID: 38190441 PMCID: PMC10851415 DOI: 10.1021\/acs.biochem.3c00536. method MX \u00b7 beamline 5.0.3, 8.2.1 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  25. Hooks GM, Ayala JC, Holley CL, Dhulipala V, Beggs GA, Perfect JR, et al. Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR. Nat Commun. 2024 Feb 7;15(1):1153. doi: 10.1038\/s41467-024-45195-1. PubMed PMID: 38326294; PubMed Central PMCID: PMC10850145. [also TOC3]<\/strong> method MX \u00b7 beamline 5.0.1, 5.0.2, 5.0.3, 8.3.1<\/em><\/li>\n\n\n\n
  26. Schumacher MA, Cannistraci E, Salinas R, Lloyd D, Messner E, Gozzi K. Structure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site. Nucleic Acids Res. 2024 Feb 9;52(3):1435-1449. doi: 10.1093\/nar\/gkad1198. PMID: 38142455; PMCID:PMC10853764. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  27. Xu J, Lei X, Li A, Li J, Li S, Chen L. Scalable production of recombinant three-finger proteins: from inclusion bodies to high quality molecular probes. Microb Cell Fact. 2024 Feb 12;23(1):48. doi: 10.1186\/s12934-024-02316-1. PubMed PMID: 38347541; PubMed Central PMCID: PMC10860255. method<\/em> MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  28. Ding D, Fang Z, Kim SC, O’Flaherty DK, Jia X, Stone TB, Zhou L, Szostak JW. Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying. J Am Chem Soc. 2024 Feb 14;146(6):3861-3871. doi: 10.1021\/jacs.3c11158. Epub 2024 Jan 31. PMID: 38293747; PMCID: PMC10870715. method MX \u00b7 beamline 2.0.1<\/em><\/li>\n\n\n\n
  29. Thompson AJ, Wu NC, Canales A, Kikuchi C, Zhu X, de Toro BF, et al. Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site. Cell Host Microbe. 2024 Feb 14;32(2):261-275.e4. doi: 10.1016\/j.chom.2024.01.003. PubMed PMID: 38307019; PubMed Central PMCID: PMC11057904. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  30. Xu X, Herdendorf TJ, Duan H, Rohlik DL, Roy S, Zhou H, Alkhateeb H, Khandelwal S, Zhou Q, Li P, Arepally GM, Walker JK, Garcia BL, Geisbrecht BV. Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl) Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212(4):689-701. doi: 10.4049\/jimmunol.2300630. PMID: 38149922; PMCID: PMC10872613. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  31. Peng W, Garcia N, Servage KA, Kohler JJ, Ready JM, Tomchick DR, Fernandez J, Orth K. “Pseudomonas effector AvrB is a glycosyltransferase that rhamnosylates plant guardee protein RIN4.” Science advances 2024 Feb 16 ;10(7):eadd5108. PMID: 38354245. PMCID: PMC10866546. method MX \u00b7 beamline BCSB \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  32. Robbins DW, Noviski MA, Tan YS, Konst ZA, Kelly A, Auger P, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67(4):2321-2336. doi: 10.1021\/acs.jmedchem.3c01007. PubMed PMID: 38300987. method MX (from the beamline, not the text) \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  33. Li FKK, Worrall LJ, Gale RT, Brown ED, Strynadka NCJ. Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance. Sci Adv. 2024 Mar;10(9):eadj3864. doi: 10.1126\/sciadv.adj3864. PubMed PMID: 38416829; PubMed Central PMCID: PMC10901376. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  34. Marcus K, Huang Y, Subramanian S, Gee CL, Gorday K, Ghaffari-Kashani S, et al. Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat Struct Mol Biol. 2024 Mar;31(3):424-435. doi: 10.1038\/s41594-023-01177-3. PubMed PMID: 38177685; PubMed Central PMCID: PMC10950542. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  35. Gao S, Hou P, Oh J, Wang D, Greenberg MM. “Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy\u00b7dG.” Journal of the American Chemical Society 2024 Mar 06 ;146(9):6274-6282. PMID: 38393762. PMCID: PMC10932878. method MX \u00b7<\/em> beamline 5.0.1, 5.0.3<\/em><\/li>\n\n\n\n
  36. d’Oelsnitz S, Diaz DJ, Kim W, Acosta DJ, Dangerfield TL, Schechter MW, et al. Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme. Nat Commun. 2024 Mar 7;15(1):2084. doi: 10.1038\/s41467-024-46356-y. PubMed PMID: 38453941; PubMed Central PMCID: PMC10920890. method<\/em> MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  37. Cuthbert BJ, Mendoza J, de Miranda R, Papavinasasundaram K, Sassetti CM, Goulding CW. The structure of Mycobacterium thermoresistibile MmpS5 reveals a conserved disulfide bond across mycobacteria. Metallomics. 2024 Mar 12;16(3). doi: 10.1093\/mtomcs\/mfae011. PubMed PMID: 38425033; PubMed Central PMCID: PMC10929441. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  38. Judge A, Sankaran B, Hu L, Palaniappan M, Birgy A, Prasad BVV, Palzkill T. “Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning.” Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 19 ;121(12):e2313513121. TOC1. PMID: 38483989. PMCID: PMC10962969. method MX \u00b7 beamline 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  39. Li H, Hardy CD, Reidl CT, Jing Q, Xue F, Cinelli M, et al. Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry. 2024 Mar 19;63(6):788-796. doi: 10.1021\/acs.biochem.3c00601. PubMed PMID: 38417024; PubMed Central PMCID: PMC10956423. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  40. Zhao B, Hu L, Kaundal S, Neetu N, Lee CH, Somoulay X, Sankaran B, Taylor GM, Dermody TS, Venkataram Prasad BV. “Structure of orthoreovirus RNA chaperone \u03c3NS, a component of viral replication factories.” Nature communications 2024 Mar 19 ;15(1):2460. PMID: 38503747. PMCID: PMC10950856. method MX \u00b7 beamline 5.0.1 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  41. Dai S, Guo L, Dey R, Guo M, Zhang X, Bates D, et al. Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Nucleic Acids Res. 2024 Mar 21;52(5):2711-2723. doi: 10.1093\/nar\/gkae036. PubMed PMID: 38281192; PubMed Central PMCID: PMC10954479. method MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  42. de Haas RJ, Brunette N, Goodson A, Dauparas J, Yi SY, Yang EC, et al. Rapid and automated design of two-component protein nanomaterials using ProteinMPNN. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2314646121. doi: 10.1073\/pnas.2314646121. PubMed PMID: 38502697; PubMed Central PMCID: PMC10990136. method MX \u00b7 beamline 5.0.1, 8.2.1, 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  43. Carney DW, Leffler AE, Bell JA, Chandrasinghe AS, Cheng C, Chang E, et al. Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity. Bioorg Med Chem. 2024 Apr 1;103:117577. doi: 10.1016\/j.bmc.2023.117577. PubMed PMID: 38518735. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  44. Ran X, Parikh P, Abendroth J, Arakaki TL, Clifton MC, Edwards TE, et al. Structural and functional characterization of FabG4 from Mycolicibacterium smegmatis. Acta Crystallogr F Struct Biol Commun. 2024 Apr 1;80(Pt 4):82-91. doi: 10.1107\/S2053230X2400356X. PubMed PMID: 38656226; PubMed Central PMCID: PMC11058512. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  45. Yang H, Kreutzer AG, Nowick JS. Supramolecular Interactions of Teixobactin Analogues in the Crystal State. J Org Chem. 2024 Apr 5;89(7):5104-5108. doi: 10.1021\/acs.joc.3c02617. PubMed PMID: 38506062; PubMed Central PMCID: PMC11002827. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  46. Lu J, Guo Y, Yin J, Chen J, Wang Y, Wang GG, Song J. “Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations.” Nature communications 2024 Apr 10 ;15(1):3111. PMID: 38600075. PMCID: PMC11006857. method MX \u00b7 beamline 5.0.2, 5.0.3<\/em><\/li>\n\n\n\n
  47. Stewart NK, Toth M, Quan P, Beer M, Buynak JD, Smith CA, et al. Restricted Rotational Flexibility of the C5\u03b1-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase. ACS Infect Dis. 2024 Apr 12;10(4):1232-1249. doi: 10.1021\/acsinfecdis.3c00683. PubMed PMID: 38511828; PubMed Central PMCID: PMC11160566. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  48. Rupert PB, Buerger M, Girard EJ, Frutoso M, Parrilla D, Ng K, et al. Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon. 2024 Apr 15;10(7):e28583. doi: 10.1016\/j.heliyon.2024.e28583. PubMed PMID: 38586421; PubMed Central PMCID: PMC10998067. method MX \u00b7 beamline 5.0.1, 5.0.2<\/em><\/li>\n\n\n\n
  49. Fang Z, Pazienza LT, Zhang J, Tam CP, Szostak JW. Catalytic Metal Ion-Substrate Coordination during Nonenzymatic RNA Primer Extension. J Am Chem Soc. 2024 Apr 17;146(15):10632-10639. doi: 10.1021\/jacs.4c00323. PubMed PMID: 38579124; PubMed Central PMCID: PMC11027144. method MX \u00b7 beamline 2.0.1, 5.0.3, 8.2.2<\/em><\/li>\n\n\n\n
  50. Holderfield M, Lee BJ, Jiang J, Tomlinson A, Seamon KJ, Mira A, et al. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature. 2024 May;629(8013):919-926. doi: 10.1038\/s41586-024-07205-6. PubMed PMID: 38589574; PubMed Central PMCID: PMC11111408. method<\/em> MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  51. Korasick DA, Buckley DP, Palpacelli A, Cursio I, Cesaroni E, Cheng J, Tanner JJ. “Biochemical, structural, and computational analyses of two new clinically identified missense mutations of ALDH7A1.” Chemico-biological interactions 2024 May 01 ;394:110993,. PMID: 38604394. PMCID: PMC11073572. method MX \u00b7 beamline 4.2.2<\/em><\/li>\n\n\n\n
  52. Chitre AS, Wu P, Walters BT, Wang X, Bouyssou A, Du X, et al. HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics. Nat Commun. 2024 May 2;15(1):3725. doi: 10.1038\/s41467-024-48014-9. PubMed PMID: 38697971; PubMed Central PMCID: PMC11066036. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  53. Rodr\u00edguez-Hern\u00e1ndez D, Fenwick MK, Zigweid R, Sankaran B, Myler PJ, Sunnerhagen P, Kaushansky A, Staker BL, Gr\u00f8tli M. “Exploring Subsite Selectivity within Plasmodium vivax N-Myristoyltransferase Using Pyrazole-Derived Inhibitors.” Journal of medicinal chemistry 2024 May 09 ;67(9):7312-7329. PMID: 38680035. PMCID: PMC11089503. method MX \u00b7 beamline 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  54. Krieger IV, Yalamanchili S, Dickson P, Engelhart CA, Zimmerman MD, Wood J, et al. Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. ACS Infect Dis. 2024 May 10;10(5):1561-1575. doi: 10.1021\/acsinfecdis.3c00592. PubMed PMID: 38577994; PubMed Central PMCID: PMC11091879. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  55. Phillips M, Malone KL, Boyle BW, Montgomery C, Kressy IA, Joseph FM, Bright KM, Boyson SP, Chang S, Nix JC, Young NL, Jeffers V, Frietze S, Glass KC. “Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains.” Journal of medicinal chemistry 2024 May 11. PMID: 38733345. PMCID: PMC11149620. method MX \u00b7 beamline 4.2.2<\/em><\/li>\n\n\n\n
  56. Tipo J, Gottipati K, Choi KH. High-resolution RNA tertiary structures in Zika virus stem-loop A for the development of inhibitory small molecules. RNA. 2024 May 16;30(6):609-623. doi: 10.1261\/rna.079796.123. PMID: 38383158; PMCID: PMC11098461. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  57. Tipo J, Gottipati K, Slaton M, Gonzalez-Gutierrez G, Choi KH. Structure of HIV-1 RRE stem-loop II identifies two conformational states of the high-affinity Rev binding site. Nat Commun. 2024 May 17;15(1):4198. doi: 10.1038\/s41467-024-48162-y. PubMed PMID: 38760344; PubMed Central PMCID: PMC11101469. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  58. Blankenship LR, Yang KS, Vulupala VR, Alugubelli YR, Khatua K, Coleman D, Ma XR, Sankaran B, Cho CD, Ma Y, Neuman BW, Xu S, Liu WR. SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme. ACS Med Chem Lett. 2024 May 20;15(6):950-957. doi: 10.1021\/acsmedchemlett.4c00146. eCollection 2024 Jun 13. PMID: 38894905. method MX \u00b7 beamline 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  59. Eren E, Watts NR, Conway JF, Wingfield PT. Myxococcus xanthus encapsulin cargo protein EncD is a flavin-binding protein with ferric reductase activity. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2400426121. doi: 10.1073\/pnas.2400426121. PubMed PMID: 38748579; PubMed Central PMCID: PMC11126975. method MX \u00b7 beamline 5.0.1, 5.0.2<\/em><\/li>\n\n\n\n
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  61. Li Y, Wei Y, Ultsch M, Li W, Tang W, Tombling B, et al. Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region. Nat Commun. 2024 May 22;15(1):4359. doi: 10.1038\/s41467-024-48655-w. PubMed PMID: 38777835; PubMed Central PMCID: PMC11111691. method MX \u00b7 beamline 5.0.1, 5.0.2<\/em><\/li>\n\n\n\n
  62. Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Vasquez YM, Wang J, Wilkinson J, Yu Z, Ye Q, Young DW, Teng M, Kim C, Matzuk MM. Reversible male contraception by targeted inhibition of serine\/threonine kinase 33. Science. 2024 May 24;384(6698):885-890. doi: 10.1126\/science.adl2688. PMID: 38781365 BL 5.0.2, TOC1. method MX \u00b7<\/em> beamline 5.0.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  63. Glenn SJ, Gentry-Lear Z, Shavlik M, Harms MJ, Asaki TJ, Baylink A. Bacterial vampirism mediated through taxis to serum. Elife. 2024 May 31;12:RP93178. doi: 10.7554\/eLife.93178. PMID: 38820052; PMCID: PMC11142651. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  64. Chang C, et al. Sugar ring alignment and dynamics underline cytarabine and gemcitabine inhibition on Pol \u03b7 catalyzed DNA synthesis. J Biol Chem. 2024 Jun 1. doi: 10.1016\/j.jbc.2024.107361. PMID: 38735473; PMCID: PMC11176770. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  65. Sampathkumar P, Jung H, Chen H, Zhang Z, Suen N, Yang Y, Huang Z, Lopez T, Benisch R, Lee SJ, Ye J, Yeh WC, Li Y. Targeted protein degradation systems to enhance Wnt signaling. Elife. 2024 Jun 7;13:RP93908. doi: 10.7554\/eLife.93908. PMID: 38847394; PMCID: PMC11161174. method MX \u00b7 beamline BCSB<\/em><\/li>\n\n\n\n
  66. Jia X, Fang Z, Kim SC, Ding D, Zhou L, Szostak JW. Diaminopurine in Nonenzymatic RNA Template Copying. J Am Chem Soc. 2024 Jun 12;146(23):15897-15907. doi: 10.1021\/jacs.4c02560. Epub 2024 May 31. PMID: 38818863; PMCID: PMC11177312. method MX \u00b7 beamline 2.0.1<\/em><\/li>\n\n\n\n
  67. Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, et al. Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature. 2024 Jul;631(8022):905-912. doi: 10.1038\/s41586-024-07699-0. PubMed PMID: 39020174. beamline 5.0.2<\/em><\/li>\n\n\n\n
  68. Ennist NM, Wang S, Kennedy MA, Curti M, Sutherland GA, Vasilev C, Redler RL, Maffeis V, Shareef S, Sica AV, Hua AS, Deshmukh AP, Moyer AP, Hicks DR, Swartz AZ, Cacho RA, Novy N, Bera AK, Kang A, Sankaran B, Johnson MP, Phadkule A, Reppert M, Ekiert D, Bhabha G, Stewart L, Caram JR, Stoddard BL, Romero E, Hunter CN, Baker D. De novo design of proteins housing excitonically coupled chlorophyll special pairs. Nat Chem Biol. 2024 Jul;20(7):906-915. doi: 10.1038\/s41589-024-01626-0. Epub 2024 Jun 3. PMID: 38831036. [also TOC2]<\/strong> method MX \u00b7 beamline 12.3.1, 5.0.1, 5.0.1 \u00b7 staff author: Banumathi Sankaran \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  69. Hariharan P, Bakhtiiari A, Liang R, Guan L. Distinct roles of the major binding residues in the cation-binding pocket of the melibiose transporter MelB. J Biol Chem. 2024 Jul;300(7):107427. doi: 10.1016\/j.jbc.2024.107427. PubMed PMID: 38823641; PubMed Central PMCID: PMC11259710. method MX \u00b7 beamline 5.0.1, 8.2.2<\/em><\/li>\n\n\n\n
  70. Schumacher MA, Singh RR, Salinas R. Structure of the E. coli nucleoid-associated protein YejK reveals a novel DNA binding clamp. Nucleic Acids Res. 2024 Jul 8;52(12):7354-7366. doi: 10.1093\/nar\/gkae459. PubMed PMID: 38832628; PubMed Central PMCID: PMC11229321. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  71. Sewa AS, Besser HA, Mathews II, Khosla C. Structural and mechanistic analysis of Ca(2+)-dependent regulation of transglutaminase 2 activity using a Ca(2+)-bound intermediate state. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2407066121. doi: 10.1073\/pnas.2407066121. PubMed PMID: 38959038; PubMed Central PMCID: PMC11252922. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  72. Wacker JN, Woods JJ, Rupert PB, Peterson A, Allaire M, Lukens WW, Gaiser AN, Minasian SG, Strong RK, Abergel RJ. Actinium chelation and crystallization in a macromolecular scaffold. Nat Commun. 2024 Jul 15;15(1):5741. doi: 10.1038\/s41467-024-50017-5. PMID: 39009580. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  73. Berhanu S, Majumder S, M\u00fcntener T, Whitehouse J, Berner C, Bera AK, Kang A, Liang B, Khan N, Sankaran B, Tamm LK, Brockwell DJ, Hiller S, Radford SE, Baker D, Vorobieva AA Sculpting conducting nanopore size and shape through de novo protein design. Science. 2024 Jul 19;385(6706):282-288. doi: 10.1126\/science.adn3796. Epub 2024 Jul 18. PMID: 39024453 (8.2.1). method MX \u00b7 beamline 8.2.1 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  74. Zhu N, Rogers WE, Heidary DK, Huxford T. Structural and biochemical analyses of the nuclear I\u03baB\u03b6 protein in complex with the NF-\u03baB p50 homodimer. Genes Dev. 2024 Jul 19;38(11-12):528-535. doi: 10.1101\/gad.351892.124. PubMed PMID: 38960718; PubMed Central PMCID: PMC11293385. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  75. Guercio AM, Gilio AK, Pawlak J, Shabek N. Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction. J Biol Chem. 2024 Aug;300(8):107593. doi: 10.1016\/j.jbc.2024.107593. PubMed PMID: 39032651; PubMed Central PMCID: PMC11350264. method MX \u00b7 beamline 8.2.1, 8.2.2 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  76. Palayam M, Yan L, Nagalakshmi U, Gilio AK, Cornu D, Boyer FD, et al. Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation. Nat Commun. 2024 Aug 1;15(1):6500. doi: 10.1038\/s41467-024-50928-3. PubMed PMID: 39090154; PubMed Central PMCID: PMC11294565. method MX \u00b7 beamline 8.2.2 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  77. Saran A, Kim HM, Manning I, Hancock MA, Schmitz C, Madej M, et al. Unveiling the molecular mechanisms of the type IX secretion system’s response regulator: Structural and functional insights. PNAS Nexus. 2024 Aug;3(8):pgae316. doi: 10.1093\/pnasnexus\/pgae316. PubMed PMID: 39139265; PubMed Central PMCID: PMC11320123. method MX \u00b7 beamline 5.0.1, 5.0.2<\/em><\/li>\n\n\n\n
  78. Sevrioukova IF. Interaction of CYP3A4 with the inhibitor cobicistat: Structural and mechanistic insights and comparison with ritonavir. Arch Biochem Biophys. 2024 Aug;758:110071. doi: 10.1016\/j.abb.2024.110071. PubMed PMID: 38909836; PubMed Central PMCID: PMC11286144. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  79. Tong AY, Tong EL, Hannani MA, Shaffer SN, Santiago D, Ferr\u00e9-D’Amar\u00e9 AR, et al. RNA thermometers are widespread upstream of ABC transporter genes in bacteria. J Biol Chem. 2024 Aug;300(8):107547. doi: 10.1016\/j.jbc.2024.107547. PubMed PMID: 38992441; PubMed Central PMCID: PMC11342760. method MX \u00b7 beamline 5.0.1, 5.0.2<\/em><\/li>\n\n\n\n
  80. Rupert PB, Buerger M, Friend DJ, Strong RK. Structural elucidation of the mesothelin-mucin-16\/CA125 interaction. Structure. 2024 Aug 8;32(8):1049-1054.e2. doi: 10.1016\/j.str.2024.04.011. PubMed PMID: 38703776; PubMed Central PMCID: PMC11316652. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  81. Lu X, Passalacqua LFM, Nodwell M, Kong KYS, Caballero-Garc\u00eda G, Dolgosheina EV, et al. Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar KD. Nucleic Acids Res. 2024 Aug 12;52(14):8039-8051. doi: 10.1093\/nar\/gkae493. PubMed PMID: 38945550; PubMed Central PMCID: PMC11317130. method MX \u00b7 beamline 5.0.1, 5.0.2<\/em><\/li>\n\n\n\n
  82. Chang C, Zhou G, Gao Y. Observing one-divalent-metal-ion-dependent and histidine-promoted His-Me family I-PpoI nuclease catalysis in crystallo. Elife. 2024 Aug 14;13. doi: 10.7554\/eLife.99960. PubMed PMID: 39141555; PubMed Central PMCID: PMC11325842. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  83. Altman PX, Ozorowski G, Stanfield RL, Haakenson J, Appel M, Parren M, et al. Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. PLoS Pathog. 2024 Sep;20(9):e1012042. doi: 10.1371\/journal.ppat.1012042. PubMed PMID: 39250525; PubMed Central PMCID: PMC11412654. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  84. Garrigues RJ, Garrison MP, Garcia BL. The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation. J Immunol. 2024 Sep 1;213(5):718-729. doi: 10.4049\/jimmunol.2400194. PubMed PMID: 38995166; PubMed Central PMCID: PMC11333171. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  85. Khudaverdyan N, Lu J, Chen X, Herle G, Song J. The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation. J Biol Chem. 2024 Sep;300(9):107633. doi: 10.1016\/j.jbc.2024.107633. PubMed PMID: 39098534; PubMed Central PMCID: PMC11401227. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  86. Sirirungruang S, Blay V, Scott YF, Pereira JH, Hammel M, Barnum CR, Adams PD, Shih PM. Structural and biochemical basis for regiospecificity of the flavonoid glycosyltransferase UGT95A1. J Biol Chem. 2024 Sep;300(9):107602. doi: 10.1016\/j.jbc.2024.107602. PMID: 39059496. [also TOC2]<\/strong> method MX \u00b7<\/em> beamline 8.2.2 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  87. Sun X, Ferguson JA, Yang K, Stanfield RL, Dyson HJ, Wright PE. Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer. Protein Sci. 2024 Sep;33(9):e5101. doi: 10.1002\/pro.5101. PubMed PMID: 39149996; PubMed Central PMCID: PMC11327909. method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  88. Zheng Q, Zhang Z, Guiley KZ, Shokat KM. Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nat Chem Biol. 2024 Sep;20(9):1114-1122. doi: 10.1038\/s41589-024-01565-w. PubMed PMID: 38443470; PubMed Central PMCID: PMC11357986. method MX \u00b7 beamline 8.2.1, 8.2.2<\/em><\/li>\n\n\n\n
  89. Elghondakly A, Jermain MD, Winkler WC, Ferr\u00e9-D’Amar\u00e9 AR. Major-groove sequence-specific RNA recognition by LoaP, a paralog of transcription elongation factor NusG. Structure. 2024 Sep 5;32(9):1488-1497.e5. doi: 10.1016\/j.str.2024.06.001. PubMed PMID: 38959899; PubMed Central PMCID: PMC11648650. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  90. Zhou G, Rusnac DV, Park H, Canzani D, Nguyen HM, Stewart L, et al. An artificial intelligence accelerated virtual screening platform for drug discovery. Nat Commun. 2024 Sep 5;15(1):7761. doi: 10.1038\/s41467-024-52061-7. PubMed PMID: 39237523; PubMed Central PMCID: PMC11377542. method<\/em> MX \u00b7 beamline 8.2.1, 8.2.2<\/em><\/li>\n\n\n\n
  91. Ogbonna EN, Terrell JR, Paul A, Farahat AA, Poon GMK, Boykin DW, et al. Single GC base pair recognition by a heterocyclic diamidine: structures, affinities, and dynamics. RSC Adv. 2024 Sep 12;14(40):29675-29682. doi: 10.1039\/d4ra05957c. PubMed PMID: 39297050; PubMed Central PMCID: PMC11408989. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  92. Gonzalez-DeWhitt KR, Ermolova N, Wang HK, Hekstra DR, Althoff T, Abramson J. Insights into VDAC Gating: Room-Temperature X-ray Crystal Structure of mVDAC-1. Biomolecules. 2024 Sep 24;14(10). doi: 10.3390\/biom14101203. PubMed PMID: 39456136; PubMed Central PMCID: PMC11505624. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  93. Hudkins RL, Allen E, Balcer A, Hoffman ID, Iyer S, Neal M, et al. Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia. J Med Chem. 2024 Sep 26;67(18):16737-16756. doi: 10.1021\/acs.jmedchem.4c01531. PubMed PMID: 39258897. method MX (from the beamline, not the text) \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  94. Bolling C, Mendez A, Taylor S, Makumire S, Reers A, Zigweid R, et al. Ternary structure of Plasmodium vivaxN-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173. Acta Crystallogr F Struct Biol Commun. 2024 Oct 1;80(Pt 10):269-277. doi: 10.1107\/S2053230X24008604. PubMed PMID: 39291304; PubMed Central PMCID: PMC11448930. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  95. Farrants H, Shuai Y, Lemon WC, Monroy Hernandez C, Zhang D, Yang S, et al. A modular chemigenetic calcium indicator for multiplexed in vivo functional imaging. Nat Methods. 2024 Oct;21(10):1916-1925. doi: 10.1038\/s41592-024-02411-6. PubMed PMID: 39304767; PubMed Central PMCID: PMC11466818. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  96. Narayanan D, et al. Ligand-induced CaMKII\u03b1 hub Trp403 flip, hub domain stacking, and modulation of kinase activity. Protein Sci. 2024 Oct 1. doi: 10.1002\/pro.5152. PMID: 39275999; PMCID: PMC11400628. method MX \u00b7 beamline 8.2.2<\/em><\/li>\n\n\n\n
  97. Rodrigues AV, et al. Characterization of lignin-degrading enzyme PmdC, which catalyzes a key step in the synthesis of polymer precursor 2-pyrone-4,6-dicarboxylic acid. J Biol Chem. 2024 Oct 1. doi: 10.1016\/j.jbc.2024.107736. PMID: 39222681; PMCID: PMC11489326. method MX \u00b7 beamline 8.2.2 \u00b7 non-<\/em> biomedical<\/em><\/li>\n\n\n\n
  98. Harold RL, Tulsian NK, Narasimamurthy R, Yaitanes N, Ayala Hernandez MG, Lee HW, et al. Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2415567121. doi: 10.1073\/pnas.2415567121. PubMed PMID: 39356670; PubMed Central PMCID: PMC11474029. method MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  99. Barkan DT, Garland K, Zhang L, Eastman RT, Hesse M, Knapp M, et al. Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness. J Med Chem. 2024 Oct 10;67(19):17454-17471. doi: 10.1021\/acs.jmedchem.4c01404. PubMed PMID: 39332817; PubMed Central PMCID: PMC11472307. method MX \u00b7 beamline 2.0.1<\/em><\/li>\n\n\n\n
  100. Yang H, Pacheco J, Kim K, Bokani A, Ito F, Ebrahimi D, et al. Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain. Nat Commun. 2024 Oct 10;15(1):8773. doi: 10.1038\/s41467-024-52671-1. PubMed PMID: 39389938; PubMed Central PMCID: PMC11467180. method<\/em> MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  101. Haley DJ, Lanning S, Henricson KE, Mardirossian AA, Cirillo I, Rahe MC, et al. Structure and Antigenicity of the Porcine Astrovirus 4 Capsid Spike. Viruses. 2024 Oct 11;16(10). doi: 10.3390\/v16101596. PubMed PMID: 39459929; PubMed Central PMCID: PMC11512355. method MX \u00b7<\/em> beamline 5.0.1<\/em><\/li>\n\n\n\n
  102. Jensen SJ, Cuthbert BJ, Garza-S\u00e1nchez F, Helou CC, de Miranda R, Goulding CW, et al. Advanced glycation end-product crosslinking activates a type VI secretion system phospholipase effector protein. Nat Commun. 2024 Oct 11;15(1):8804. doi: 10.1038\/s41467-024-53075-x. PubMed PMID: 39394186; PubMed Central PMCID: PMC11470151. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  103. Agrawal P, Knudsen ML, MacCamy A, Hurlburt NK, Khechaduri A, Salladay KR, et al. Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env. J Virol. 2024 Oct 22;98(10):e0074424. doi: 10.1128\/jvi.00744-24. PubMed PMID: 39240111; PubMed Central PMCID: PMC11495006. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  104. Scharffenberger SC, Wan YH, Homad LJ, Kher G, Haynes AM, Poudel B, et al. Targeting RSV-neutralizing B cell receptors with anti-idiotypic antibodies. Cell Rep. 2024 Oct 22;43(10):114811. doi: 10.1016\/j.celrep.2024.114811. PubMed PMID: 39383036; PubMed Central PMCID: PMC11496930. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  105. Peng Y, Moffat JG, DuPai C, Kofoed EM, Skippington E, Modrusan Z, et al. Differential effects of inosine monophosphate dehydrogenase (IMPDH\/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli. J Bacteriol. 2024 Oct 24;206(10):e0010224. doi: 10.1128\/jb.00102-24. PubMed PMID: 39235234; PubMed Central PMCID: PMC11500612. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  106. Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, et al. Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell. 2024 Oct 31;187(22):6379-6392.e17. doi: 10.1016\/j.cell.2024.08.017. PubMed PMID: 39255801; PubMed Central PMCID: PMC11531380. method MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  107. Thomas GM, Quirk S, Lieberman RL. Structure and stability of an apo thermophilic esterase that hydrolyzes polyhydroxybutyrate. Acta Crystallogr D Struct Biol. 2024 Nov 1;80(Pt 11):791-799. doi: 10.1107\/S2059798324009707. PubMed PMID: 39441250; PubMed Central PMCID: PMC11544428. method MX \u00b7 beamline 5.0.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  108. Kumar RP, Matos JO, Black BY, Ellenburg WH, Chen J, Patterson M, et al. Crystal Structure of Caryolan-1-ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction. Biochemistry. 2024 Nov 5;63(21):2904-2915. doi: 10.1021\/acs.biochem.4c00547. PubMed PMID: 39400323; PubMed Central PMCID: PMC12068512. method MX \u00b7 beamline 8.2.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  109. Andrade Meirelles M, Almeida VM, Sullivan JR, de Toledo I, Dos Reis CV, Cunha MR, Zigweid R, Shim A, Sankaran B, Woodward EL, Seibold S, Liu L, Mian MR, Battaile KP, Riley J, Duncan C, Simeons FRC, Ferguson L, Joji H, Read KD, Lovell S, Staker BL, Behr MA, Pilli RA, Cou\u00f1ago RM. Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens. J Med Chem. 2024 Nov 14;67(21):19143-19164. doi: 10.1021\/acs.jmedchem.4c01594. Epub 2024 Oct 28. PMID: 39468773. method MX \u00b7 beamline 8.2.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  110. Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, et al. Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases. Nat Commun. 2024 Nov 15;15(1):9899. doi: 10.1038\/s41467-024-54126-z. PubMed PMID: 39548056; PubMed Central PMCID: PMC11568203. method<\/em> MX \u00b7 beamline 5.0.1<\/em><\/li>\n\n\n\n
  111. Kaylen R Meeks , Alexandra N Bogner , Jay C Nix, John J Tanner Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-\u03b3-semialdehyde Dehydrogenase. Molecules. 2024 Nov 16;29(22):5408. doi: 10.3390\/molecules29225408. PMID: 39598797 PMCID: PMC11596857. method MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  112. Alboreggia G, Udompholkul P, Rodriguez I, Blaha G, Pellecchia M. Targeted degradation of Pin1 by protein-destabilizing compounds. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2403330121. doi: 10.1073\/pnas.2403330121. Epub 2024 Nov 12. Erratum in: Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2424805121. doi: 10.1073\/pnas.2424805121. PMID: 39531501; PMCID: PMC11588135. (5.0.3). method MX \u00b7 beamline 5.0.3<\/em><\/li>\n\n\n\n
  113. Jimmidi R, Monsivais D, Ta HM, Sharma KL, Bohren KM, Chamakuri S, Liao Z, Li F, Hakenjos JM, Li JY, Mishina Y, Pan H, Qin X, Robers MB, Sankaran B, Tan Z, Tang S, Vasquez YM, Wilkinson J, Young DW, Palmer SS, MacKenzie KR, Kim C, Matzuk MM. Discovery of highly potent and ALK2\/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2413108121. doi: 10.1073\/pnas.2413108121. Epub 2024 Nov 14. PMID: 39541346. method<\/em> MX \u00b7 beamline 5.0.2 \u00b7 staff author: Banumathi Sankaran<\/em><\/li>\n\n\n\n
  114. Phan HN, Swartz PD, Gangopadhyay M, Guo Y, Smirnov AI, Makris TM. Assembly of a Heterobimetallic Fe\/Mn Cofactor in the para-Aminobenzoate Synthase Chlamydia Protein Associating with Death Domains (CADD) Initiates Long-Range Radical Hole-Hopping. Biochemistry. 2024 Nov 19;63(22):3020-3029. doi: 10.1021\/acs.biochem.4c00326. PubMed PMID: 39471288; PubMed Central PMCID: PMC12186997. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  115. Ennis AF, Cochrane CS, Dome PA, Jeong P, Yu J, Lee H, et al. Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales. JACS Au. 2024 Nov 25;4(11):4383-4393. doi: 10.1021\/jacsau.4c00731. PubMed PMID: 39610720; PubMed Central PMCID: PMC11600146. method MX \u00b7 beamline 5.0.2, 5.0.3<\/em><\/li>\n\n\n\n
  116. Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, et al. An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Rep. 2024 Nov 26;43(11):114929. doi: 10.1016\/j.celrep.2024.114929. PubMed PMID: 39504242; PubMed Central PMCID: PMC12180444. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  117. Cuthbert BJ, Chen X, Burley K, Batot G, Contreras H, Dixon S, et al. Structural Characterization of Mycobacterium tuberculosis Encapsulin in Complex with Dye-Decolorizing Peroxide. Microorganisms. 2024 Nov 30;12(12). doi: 10.3390\/microorganisms12122465. PubMed PMID: 39770668; PubMed Central PMCID: PMC11676171. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  118. Cowie AE, Pereira JH, DeGiovanni A, McAndrew RP, Palayam M, Peek JO, Muchlinski AJ, Yoshikuni Y, Shabek N, Adams PD, Zerbe P. The crystal structure of Grindelia robusta 7,13-copalyl diphosphate synthase reveals active site features controlling catalytic specificity. J Biol Chem. 2024 Dec;300(12):107921. doi: 10.1016\/j.jbc.2024.107921. PMID: 39454950. method MX \u00b7 beamline 8.2.2 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
  119. Reyes RA, Raghavan SSR, Hurlburt NK, Introini V, Bol S, Kana IH, et al. Broadly inhibitory antibodies to severe malaria virulence proteins. Nature. 2024 Dec;636(8041):182-189. doi: 10.1038\/s41586-024-08220-3. PubMed PMID: 39567685; PubMed Central PMCID: PMC12338075. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  120. Batka AE, Thomas WC, Tudorica DA, Sayler RI, Marletta MA. Second-Sphere Histidine Catalytic Function in a Fungal Polysaccharide Monooxygenase. Biochemistry. 2024 Dec 3;63(23):3136-3146. doi: 10.1021\/acs.biochem.4c00527. PubMed PMID: 39563485. method MX \u00b7 beamline 5.0.2<\/em><\/li>\n\n\n\n
  121. Fenwick MK, Pierce PG, Abendroth J, Barrett KF, Barrett LK, Bowatte K, et al. Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens. Commun Biol. 2024 Dec 5;7(1):1622. doi: 10.1038\/s42003-024-07175-5. PubMed PMID: 39639052; PubMed Central PMCID: PMC11621423. method MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  122. Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, et al. A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification. Cell. 2024 Dec 12;187(25):7196- 7213.e26. doi: 10.1016\/j.cell.2024.09.026. PubMed PMID: 39383863; PubMed Central PMCID: PMC11645210. method MX \u00b7 beamline 8.2.1<\/em><\/li>\n\n\n\n
  123. Uyeda KS, Follmer AH, Borovik AS. Selective oxidation of active site aromatic residues in engineered Cu proteins. Chem Sci. 2024 Dec 18;16(1):98-103. doi: 10.1039\/d4sc06667g. PubMed PMID: 39600509; PubMed Central PMCID: PMC11587884. method MX \u00b7 beamline 5.0.1, 5.0.2, 5.0.3<\/em><\/li>\n\n\n\n
  124. B\u00fcrger M, Peterson D, Chory J. Strigolactones initiate the formation of haustorium-like structures in Castilleja. iScience. 2024 Dec 20;27(12):111491. doi: 10.1016\/j.isci.2024.111491. PubMed PMID: 39759020; PubMed Central PMCID: PMC11697714. method MX \u00b7 beamline 8.2.2 \u00b7 non-biomedical<\/em><\/li>\n<\/ol>\n\n\n\n

    TOC2 \u2014 High Quality and High Throughput SAXS (33)<\/h2>\n\n\n\n
      \n
    1. Yadav P, Gupta M, Wazahat R, Islam Z, Tsutakawa SE, Kamthan M, Kumar P. \u201cStructural basis for the role of C-terminus acidic tail of Saccharomyces cerevisiae ubiquitin-conjugating enzyme (Rad6) in E3 ligase (Bre1) mediated recognition of histones.\u201d International journal of biological macromolecules 2024 Jan ;254(Pt 2):127717 PMID: 37923031. method SAXS \u00b7 beamline 12.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    2. Murray DT, Ge X, Schut GJ, Rosenberg DJ, Hammel M, Bierma JC, Hille R, Adams MWW, Hura GL. \u201cCorrelating Conformational Equilibria with Catalysis in the Electron Bifurcating EtfABCX of Thermotoga maritima.\u201d Biochemistry 2024 Jan 02 ;63(1):128-140 PMID: 38013433; PMCID: PMC10765413. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Gregory L. Hura; Michal Hammel \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    3. Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH. \u201cConformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.\u201d eLife 2024 Jan 08 ;12 PMID: 38189455; PMCID: PMC10945472. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    4. Rosenberg DJ, Cunningham FJ, Hubbard JD, Goh NS, Wang JW, Nishitani S, Hayman EB, Hura GL, Landry MP, Pinals RL. \u201cMapping the Morphology of DNA on Carbon Nanotubes in Solution Using X-ray Scattering Interferometry.\u201d Journal of the American Chemical Society 2024 Jan 10 ;146(1):386-398 PMID: 38158616. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Gregory L. Hura \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    5. Roger M, Leone P, Blackburn NJ, Horrell S, Chicano TM, Biaso F, Giudici-Orticoni MT, Abriata LA, Hura GL, Hough MA, Sciara G, Ilbert M. \u201cBeyond the coupled distortion model: structural analysis of the single domain cupredoxin AcoP, a green mononuclear copper centre with original features.\u201d Dalton transactions (Cambridge, England : 2003) 2024 Jan 23 ;53(4):1794-1808 PMID: 38170898; PMCID: PMC10804444. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Gregory L. Hura \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    6. Luo Y, Hao H, Wang Z, Ong CY, Dutcher R, Xu Y, Liu J, Pedersen LC, Xu D. \u201cHeparan sulfate promotes TRAIL-induced tumor cell apoptosis.\u201d eLife 2024 Jan 24 ;12 PMID: 38265424; PMCID: PMC10945736. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    7. Bennett AL, Edwards R, Kosheleva I, Saunders C, Bililign Y, Williams A, Bubphamala P, Manosouri K, Anasti K, Saunders KO, Alam SM, Haynes BF, Acharya P, Henderson R. \u201cMicrosecond dynamics control the HIV-1 Envelope conformation.\u201d Science advances 2024 Feb 02 ;10(5):eadj0396 PMID: 38306419; PMCID: PMC10836732. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    8. Zhao W, Lin JS, Nielsen JE, S\u00f8rensen K, Wadurkar AS, Ji J, Barron AE, Nangia S, Libera MR. \u201cSupramolecular Peptoid Structure Strengthens Complexation with Polyacrylic Acid Microgels.\u201d Biomacromolecules 2024 Feb 12 ;25(2):1274-1281 PMID: 38240722. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    9. Hu Q, Botuyan MV, Mer G. \u201cIdentification of a conserved \u03b1-helical domain at the N terminus of human DNA methyltransferase 1.\u201d The Journal of biological chemistry 2024 Mar ;300(3):105775 PMID: 38382673; PMCID: PMC10950863. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    10. Milano CR, Ur SN, Gu Y, Zhang J, Allison R, Brown G, Neale MJ, Tromer EC, Corbett KD, Hochwagen A. \u201cChromatin binding by HORMAD proteins regulates meiotic recombination initiation.\u201d The EMBO journal 2024 Mar ;43(5):836-867. PMID: 38332377; PMCID: PMC10907721. method SAXS \u00b7 beamline 12.3.1 \u00b7<\/em> non-biomedical<\/em><\/li>\n\n\n\n
    11. Balakrishnan S, Adolph M, Tsai MS, Akizuki T, Gallagher K, Cortez D, Chazin WJ. \u201cStructure of RADX and mechanism for regulation of RAD51 nucleofilaments.\u201d Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 19 ;121(12):e2316491121 PMID: 38466836. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    12. Dykeman-Bermingham PA, Bogen MP, Chittari SS, Grizzard SF, Knight AS. \u201cTailoring Hierarchical Structure and Rare Earth Affinity of Compositionally Identical Polymers via Sequence Control.\u201d Journal of the American Chemical Society 2024 Mar 27 ;146(12):8607-8617. PMID: 38470430 DOI: 10.1021\/jacs.4c00440 method SAXS \u00b7 beamline 12.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    13. Tamilselvan E, Sotomayor M. \u201cCELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain.\u201d Structure. 2024 Apr 04 ;32(4):476-491.e5 PMID: 38307021. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    14. Brosey CA, TM, Shen R, Moiani D, Burnett K, Hura GL, Jones DE, Tainer JA. \u201cChemical screening by time-resolved X-ray scattering to discover allosteric probes.\u201d Nature chemical biology 2024 Apr 26. PMID: 38671223 PMCID: PMC11358040 DOI: 10.1038\/s41589-024-01609-1 [also TOC3]<\/em><\/strong> method MX; SAXS \u00b7<\/em> beamline 12.3.1 \u00b7 staff author: Gregory L. Hura<\/em><\/li>\n\n\n\n
    15. Salinas ND, Ma R, McAleese H, Ouahes T, Long CA, Miura K, Lambert LE, Tolia NH. \u201cA Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity.\u201d Vaccines 2024 May 16 ;12(5) PMID: 38793797; PMCID: PMC11125772. method SAXS<\/em> beamline 12.3.1<\/em><\/li>\n\n\n\n
    16. Chinnam NB, Thapar R, Arvai AS, Sarker AH, Soll JM, Paul T, Syed A, Rosenberg DJ, Hammel M, Bacolla A, Katsonis P, Asthana A, Tsai MS, Ivanov I, Lichtarge O, Silverman RH, Mosammaparast N, Tsutakawa SE, Tainer JA. \u201cASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif ed to a two-histidine phosphodiesterase.\u201d The Journal of biological chemistry 2024 Jun ;300(6):107368 PMID: 38750793; PMCID: PMC11214414. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Michal Hammel<\/em><\/li>\n\n\n\n
    17. Edman NI, Phal A, Redler RL, Schlichthaerle T, Srivatsan SR, Ehnes DD, Etemadi A, An SJ, Favor A, Li Z, Praetorius F, Gordon M, Vincent T, Marchiano S, Blakely L, Lin C, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Zheng Y, Murry CE, Schweppe DK, Freedman BS, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. \u201cModulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.\u201d Cell 2024 Jul 11 ;187(14):3726-3740.e43 PMID: 38861993. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    18. Jiang H, Jude KM, Wu K, Fallas J, Ueda G, Brunette TJ, Hicks DR, Pyles H, Yang A, Carter L, Lamb M, Li X, Levine PM, Stewart L, Garcia KC, Baker D. \u201cDe novo design of buttressed loops for sculpting protein functions.\u201d Nature chemical biology 2024 Aug ;20(8):974-980 PMID: 38816644; PMCID: PMC11288887. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    19. Hackett JC, Krueger S, Urban VS, Z\u00e1rate-P\u00e9rez F. \u201cSmall angle scattering reveals the orientation of cytochrome P450 19A1 in lipoprotein nanodiscs.\u201d Journal of inorganic biochemistry 2024 Aug ;257:112579 PMID: 38703512. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    20. Mishra N, Gido CD, Herdendorf TJ, Hammel M, Hura GL, Fu ZQ, Geisbrecht BV. \u201cS. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases.\u201d The Journal of biological chemistry 2024 Aug 02 :107627 PMID: 39098536. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Gregory L. Hura; Michal Hammel<\/em><\/li>\n\n\n\n
    21. Semper C, Watanabe N, Karimullina E, Patel DT, Di Leo R, Castellanos M, Patel DH, Chaconas G, Savchenko A. \u201cStructure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain.\u201d Nucleic acids research 2024 Aug 12 ;52(14):8431-8442 PMID: 38979576. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    22. Fan Y, Rigas D, Kim LJ, Chang FP, Zang N, McKee K, Kemball CC, Yu Z, Winkler P, Su WC, Jessen P, Hura GL, Chen T, Koenig SG, Nagapudi K, Leung D, Yen CW. \u201cPhysicochemical and structural insights into lyophilized mRNA-LNP from lyoprotectant and buffer screenings.\u201d Journal of controlled release: official journal of the Controlled Release Society 2024 Sep ;373:727-737 PMID: 39059500. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Gregory L. Hura<\/em><\/li>\n\n\n\n
    23. Khan SA, Hicks A, Leite WC, Byrnes J, Gorai B, Mroginski MA, O\u2019Neill H, Miller AF. \u201cExtended conformations of bifurcating electron transfer flavoprotein constitute up to half the population, possibly mediating conformational change.\u201d Chemical science 2024 Oct 23 ;15(45):18796-817 PMID: 39512923 PMCID: PMC11536132 DOI: 10.1039\/d4sc04544k. method SAXS \u00b7 beamline 12.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    24. Allert MJ, Kumar S, Wang Y, Beese LS, Hellinga HW. \u201cAccurate Identification of Periplasmic Urea-binding Proteins by Structure- and Genome Context-assisted Functional Analysis.\u201d Journal of molecular biology 2024 Nov 15 ;436(22):168780. PMID: 39241982 DOI: 10.1016\/j.jmb.2024.168780 method SAXS \u00b7<\/em> beamline 12.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    25. Kc S, Nguyen KH, Nicholson V, Walgren A, Trent T, Gollub E, Romero-Perez PS, Holehouse AS, Sukenik S, Boothby TC. \u201cDisordered proteins interact with the chemical environment to tune their protective function during drying.\u201d eLife 2024 Nov 19 ;13 PMID: 39560655; PMCID: PMC11575898 DOI: 10.7554\/eLife.97231. method SAXS \u00b7 beamline 12.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    26. McElroy CA, Ihms EC, Kumar Yadav D, Holmquist ML, Wadhwa V, Wysocki VH, Gollnick P, Foster MP. \u201cSolution structure, dynamics and tetrahedral assembly of Anti-TRAP, a homo-trimeric triskelion-shaped regulator of tryptophan biosynthesis in Bacillus subtilis.\u201d Journal of structural biology: X 2024 Dec;10:100103. PMID: 39035014; PMCID: PMC11255114. method SAXS \u00b7 beamline 12.3.1 \u00b7 non-<\/em> biomedical<\/em><\/li>\n\n\n\n
    27. Chittari SS, Dykeman-Bermingham PA, Bogen MP, Knight AS. Structure-Function Insights into Thermoresponsive Copolymers as Lanthanide Precipitants. J Am Chem Soc. 2024 Dec 11;146(49):33499-33508. doi: 10.1021\/jacs.4c10427. PubMed PMID: 39586773. method SAXS \u00b7 beamline 12.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    28. Cartwright M, Parakra R, Oduwole A, Zhang F, Deredge DJ, Smith AT. \u201cIdentification of an Intrinsically Disordered Region (IDR) in Arginyltransferase 1 (ATE1).\u201d Biochemistry 2024 Dec 17 ;63(24):3236-3249 PMID: 39642180. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n\n\n\n
    29. Kibler RD, Lee S, Kennedy MA, Wicky BIM, Lai SM, Kostelic MM, Carr A, Li X, Chow CM, Nguyen TK, Carter L, Wysocki VH, Stoddard BL, Baker D. \u201cDesign of pseudosymmetric protein hetero-oligomers.\u201d Nature communications 2024 Dec 18 ;15(1):10684. PMID: 39695145 PMCID: PMC11655659 DOI: 10.1038\/s41467-024-54913-8 [also TOC1]<\/em><\/strong> method MX, SAXS \u00b7 beamline 12.3.1, 5.0.2<\/em><\/li>\n\n\n\n
    30. Sholes A, Asongakap R, Jaconski S, Monroe J, Berndsen CE. \u201cPotassium cations expand the conformation ensemble of Arabidopsis thaliana \u03b2-amylase2 (BAM2).\u201d microPublication biology 2024 ;2024 PMID: 39109193; PMCID: PMC11301517. method SAXS \u00b7 beamline 12.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
    31. Ruocco V, Gr\u00fcnwald-Gruber C, Rad B, Tscheliessnig R, Hammel M, Strasser R. \u201cEffects of N-glycans on the structure of human IgA2.\u201d Frontiers in molecular biosciences 2024 ;11:1390659 PMID: 38645274; PMCID: PMC11026580. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Michal Hammel<\/em><\/li>\n\n\n\n
    32. Kim LJ, Shin D, Leite WC, O\u2019Neill H, Ruebel O, Tritt A, Hura GL. \u201cSimple Scattering: Lipid nanoparticle structural data repository.\u201d Frontiers in molecular biosciences 2024 ;11:1321364 PMID: 38584701; PMCID: PMC10998447. method SAXS \u00b7 beamline 12.3.1 \u00b7 staff author: Gregory L. Hura<\/em><\/li>\n\n\n\n
    33. Nelson AD, Wang L, Laffey KG, Becher LRE, Parks CA, Hoffmann MM, Galeano BK, Mangalam A, Teixeiro E, White TA, Schrum AG, Cannon JF, Gil D. \u201cRigid crosslinking of the CD3 complex leads to superior T cell stimulation.\u201d Frontiers in immunology 2024 ;15:1434463 PMID: 39281668; PMCID: PMC11392757. method SAXS \u00b7 beamline 12.3.1<\/em><\/li>\n<\/ol>\n\n\n\n

      TOC3 \u2014 Flexible Macromolecular Crystallography (MX) (16)<\/h2>\n\n\n\n
        \n
      1. Song, Y., X. Cai, M. Wang, D. Du, Y. Lin, and C.-L. Chen, \u201cAssembly of highly efficient aqueous light-harvesting system from sequence-defined peptoids for cytosolic microRNA detection,\u201d Nano Research 17, 788-796 (2024). (doi:10.1007\/s12274-023-6008-0). No PMID. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      2. Mendez D, Holton JM, Lyubimov AY, Hollatz S, Mathews II, Cichosz A, Martirosyan V, Zeng T, Stofer R, Liu R, Song J, McPhillips S, Soltis M, Cohen AE. Deep residual networks for crystallography trained on synthetic data. Acta Crystallogr D Struct Biol. 2024 Jan 1;80(Pt 1):26-43. doi: 10.1107\/S2059798323010586. Epub 2024 Jan 1. PMID: 38164955; PMCID: PMC10833344. method MX \u00b7<\/em> beamline 8.3.1 \u00b7 staff author: James Holton<\/em><\/li>\n\n\n\n
      3. Ali BA, Judy RM, Chowdhury S, Jacobsen NK, Castanzo DT, Carr KL, Richardson CD, Lander GC, Martin A, Gardner BM. \u201cThe N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1.\u201d The Journal of biological chemistry 2024 Jan ;300(1):105504. PMID: 38036174; PMCID: PMC10777020. (BL 8.3.1, TOC3) method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      4. Sch\u00f6nherr H, et al. Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc Natl Acad Sci U S A. 2024 Feb 6. doi: 10.1073\/pnas.2317756121. PMID: 38300868; PMCID: PMC10861881. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      5. Velagapudi UK, et al. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem J. 2024 Mar 20. doi: 10.1042\/BCJ20230406. PMID: 38372302; PMCID: PMC11070930. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      6. Lu L, et al. De novo design of drug-binding proteins with predictable binding energy and specificity. Science. 2024 Apr 5. doi: 10.1126\/science.adl5364. PMID: 38574125; PMCID: PMC11290694. method MX<\/em> beamline 8.3.1<\/em><\/li>\n\n\n\n
      7. Rakotoharisoa RV, et al. Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling. J Am Chem Soc. 2024 Apr 10. doi: 10.1021\/jacs.4c00677. PMID: 38532610. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      8. Zheng R, Zhao M, Du JS, Sudarshan TR, Zhou Y, Paravastu AK, et al. Assembly of short amphiphilic peptoids into nanohelices with controllable supramolecular chirality. Nat Commun. 2024 Apr 16;15(1):3264. doi: 10.1038\/s41467-024-46839-y. PubMed PMID: 38627405; PubMed Central PMCID: PMC11021492. method MX \u00b7 beamline 8.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
      9. Parkins A, Pilien AVR, Wolff AM, Argueta C, Vargas J, Sadeghi S, et al. The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J Med Chem. 2024 May 9;67(9):7359-7372. doi: 10.1021\/acs.jmedchem.4c00177. PubMed PMID: 38670943. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      10. Shao L, Hu D, Zheng SL, Trinh TKH, Zhou W, Wang H, et al. Hierarchical Self-Assembly of Multidimensional Functional Materials from Sequence-Defined Peptoids. Angew Chem Int Ed Engl. 2024 Jun 10;63(24):e202403263. doi: 10.1002\/anie.202403263. PubMed PMID: 38657031. method MX \u00b7<\/em> beamline 8.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
      11. D\u00edaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken S, Locksley RM, Fraser JS. Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. Elife. 2024 Jun 17;12:RP89918. doi: 10.7554\/eLife.89918. PMID:38884443; PMCID: PMC11182645. (BL 8.3.1, TOC3) method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      12. Beernink PT, et al. Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody. JACS Au. 2024 Jul 5. doi: 10.1021\/jacsau.4c00359. PMID: 39055159; PMCID: PMC11267536. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      13. Weaver J, Craven GB, Tram L, Chen H, Taunton J. Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network. J Am Chem Soc. 2024 Sep 4;146(35):24233-24237. doi: 10.1021\/jacs.4c04314. PubMed PMID: 39177126. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      14. Nadel CM, et al. Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP. Nat Commun. 2024 Sep 12. doi: 10.1038\/s41467-024-52075-1. PMID: 39266525; PMCID: PMC11393453. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n\n\n\n
      15. Del Rio Flores A, et al. Enzymatic synthesis of azide by a promiscuous N-nitrosylase. Nat Chem. 2024 Dec 1. doi: 10.1038\/s41557-024-01646-2. PMID: 39333393; PMCID: PMC11611683. method MX \u00b7<\/em> beamline 8.3.1 \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
      16. Bragagnolo N, et al. The 1.3 \u00c5 resolution structure of the truncated group Ia type IV pilin from Pseudomonas aeruginosa strain P1. Acta Crystallogr D Struct Biol. 2024 Dec 1. doi: 10.1107\/S205979832401132X. PMID: 39607821; PMCID: PMC11626772. method MX \u00b7 beamline 8.3.1<\/em><\/li>\n<\/ol>\n\n\n\n

        TOC4 \u2014 High-Throughput X-Ray Mass Spectrometry (XFMS) (4)<\/h2>\n\n\n\n
          \n
        1. He L, McAndrew R, Barbu R, Gifford G, Halacoglu C, Drouin-Allaire C, Weber L, Kristensen LG, Gupta S, Chen Y, Petzold CJ, Allaire M, Li KH, Ralston CY, Gochin M. Structure and Interactions of HIV-1 gp41 CHR-NHR Reverse Hairpin Constructs Reveal Molecular Determinants of Antiviral Activity. J Mol Biol. 2024 Aug 15;436(16):168650. doi: 10.1016\/j.jmb.2024.168650. Epub 2024 Jun 10. PMID: 38866091; PMCID: PMC11297672 [also TOC1]<\/em><\/strong> method: MX; XFMS \u00b7 beamline 3.3.1, 5.0.1, 5.0.2 \u00b7 staff author: Corie<\/em> Y. Ralston; Sayan Gupta<\/em><\/li>\n\n\n\n
        2. Kristensen LG, Gupta S, Chen Y, Petzold CJ, Ralston CY. Residue-Specific Epitope Mapping of the PD-1\/Nivolumab Interaction Using X-ray Footprinting Mass Spectrometry. Antibodies (Basel). 2024 Sep 19;13(3):77. doi: 10.3390\/antib13030077. PMID: 39311382PMCID: PMC11417893 DOI: 10.3390\/antib13030077. method: XFMS \u00b7 beamline 3.3.1\u00b7 staff author: Corie Y. Ralston; Sayan Gupta<\/em><\/li>\n\n\n\n
        3. Sutter M, Utschig LM, Niklas J, Paul S, Kahan DN, Gupta S, Poektov OG, Ferlez BH, Tefft NM, TerAvest MA, Hickey DP, Vermaas JV, Ralston CY, Kerfeld CA. Electrochemical cofactor recycling of bacterial microcompartments. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49): e2414220121. PMID: 39585991 PMCID: PMC11626177 DOI: 10.1073\/pnas.2414220121. method: XFMS \u00b7 beamline 3.3.1\u00b7 staff author: Corie Y. Ralston \u00b7 non-biomedical<\/em><\/li>\n\n\n\n
        4. S. Raza, D. Sarkar, L.G. Chan, J. Mae, M. Sutter, C.J. Petzold, C.A. Kerfeld, C.Y. Ralston, S. Gupta, J.V. Vermaas. Comparative Pore Structure and Dynamics for Bacterial Microcompartment Shell Protein Assemblies in Sheets or Shells, ACS Omega, July 18, 2024, doi.org\/10.1021\/acsomega.4c02406 PMID: 39184480 PMCID: PMC11339822. method: XFMS \u00b7 beamline 3.3.1\u00b7 staff author: Corie Y. Ralston; Sayan Gupta \u00b7 non-biomedical<\/em><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

          177 publications from all four TOCs, listed in order from TOC1 \u2013 TOC4. TOC1 \u2014 Rapid Response Crystallography (124) TOC2 \u2014 High Quality and High Throughput SAXS (33) TOC3 \u2014…
          Read more<\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3858","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/pages\/3858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/comments?post=3858"}],"version-history":[{"count":1,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/pages\/3858\/revisions"}],"predecessor-version":[{"id":3859,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/pages\/3858\/revisions\/3859"}],"wp:attachment":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/media?parent=3858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}