{"id":3579,"date":"2024-07-01T14:17:10","date_gmt":"2024-07-01T21:17:10","guid":{"rendered":"https:\/\/als-enable.lbl.gov\/wordpress\/?p=3579"},"modified":"2024-07-01T14:18:43","modified_gmt":"2024-07-01T21:18:43","slug":"time-resolved-saxs-screen-of-small-molecule-drug-candidates","status":"publish","type":"post","link":"https:\/\/als-enable.lbl.gov\/wordpress\/2024\/07\/01\/time-resolved-saxs-screen-of-small-molecule-drug-candidates\/","title":{"rendered":"Time-Resolved SAXS Screen of Small-Molecule Drug Candidates"},"content":{"rendered":"<img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-3539\" src=\"http:\/\/als-enable.lbl.gov\/wordpress\/wp-content\/uploads\/Biochem-cover.png\" alt=\"\" width=\"1104\" height=\"1474\" \/>SIBYLS made the news for work on time-resolved, high-throughput, small-angle\nx-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the\nscreening of small-molecule drug candidates, and providing insight into how\nthey stimulate structural transitions in protein targets.\n\n<!-- \/wp:post-content --><!-- wp:paragraph -->\n\n<strong>Publication:<\/strong> C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K.\nBurnett, G.L. Hura, D.E. Jones, and J.A. Tainer, \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41589-024-01609-1\">Chemical screening by\ntime-resolved X-ray scattering to discover allosteric probes<\/a>,\u201d <em>Nat.\nChem. Biol.<\/em> (2024), doi:10.1038\/s41589-024-01609-1.\n\n<!-- \/wp:paragraph --><!-- wp:paragraph -->\n\nRead the article in ALS News <a href=\"https:\/\/als.lbl.gov\/time-resolved-saxs-screen-of-small-molecule-drug-candidates\/\">here.<\/a>\n\n<!-- \/wp:paragraph -->","protected":false},"excerpt":{"rendered":"<p>SIBYLS made the news for work on time-resolved, high-throughput, small-angle x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the screening of small-molecule drug candidates, and providing insight into&hellip; <br \/> <a class=\"read-more\" href=\"https:\/\/als-enable.lbl.gov\/wordpress\/2024\/07\/01\/time-resolved-saxs-screen-of-small-molecule-drug-candidates\/\">Read more<\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3579","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/posts\/3579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/comments?post=3579"}],"version-history":[{"count":2,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/posts\/3579\/revisions"}],"predecessor-version":[{"id":3581,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/posts\/3579\/revisions\/3581"}],"wp:attachment":[{"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/media?parent=3579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/categories?post=3579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/als-enable.lbl.gov\/wordpress\/wp-json\/wp\/v2\/tags?post=3579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}