How Proteins Remodel DNA in Bacteria under Stress

ALS-ENABLE beamlines use multiscale, multimodal visualization techniques to clarify how proteins remodel bacterial DNA in response to stressful environments. At the mesoscale, small-angle x-ray scattering (SAXS) at Beamline 12.3.1 made it possible to determine the overall shapes of HU–DNA complexes in solution. At the nanoscale, protein crystallography at Beamline 8.3.1 allowed identification of the molecular-level mechanisms that mediate DNA bundling. Read more about it here.