ALS-ENABLE scientist, Jay Nix at the MBC beamline 4.2.2 participated in the structure solution for a recently published paper in Cell, Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.
SIBYLS is excited to announce we have a biochemist postdoc fellow opening. This is a great opportunity to work with experienced and innovative scientist in the field of structural biology. We are looking for someone who wants to develop and apply biology for multi-component biological macromolecules. You will be a part of a team that… Read more
ALS-ENABLE beamlines use multiscale, multimodal visualization techniques to clarify how proteins remodel bacterial DNA in response to stressful environments. At the mesoscale, small-angle x-ray scattering (SAXS) at Beamline 12.3.1 made it possible to determine the overall shapes of HU–DNA complexes in solution. At the nanoscale, protein crystallography at Beamline 8.3.1 allowed identification of the molecular-level… Read more
A huge congratulations to the team of Doudna and Charpentier who received the Nobel Prize in Chemistry this year for the development of a new method of genome editing, namely, the much used CRISPR system. Dounda did much of her early structural work on this system using several of the ALS-ENABLE beamlines (though at the time these beamlines were not banded together under the ALS-ENABLE umbrella). We are very proud! Here is a link to a list of publications resulting from work at our beamlines.
Even though we had to hold our BioSAXS workshop virtually this year, it turned out to be one of our best ever. We had more 70 participants over the two day workshop, zooming in from all over the US and parts of Europe! The latest advances in SAXS studies on biological systems were discussed, along… Read more
The SIBYLS group is holding a virtual workshop and tutorial during the ALS User Meeting. This workshop is designed for current and future SIBYLS and ALS-ENABLE users. We will provide participants with software tutorial sessions, have fantastic speakers and much, much more. For more details and information on how to register go to our SIBYLS… Read more
At the ALS, X-ray Footprinting is a structural biology method that is available to users on beamline 3.2.1. Although X-ray Footprinting is not currently funded through ALS-ENABLE, the method serves a similar user base, and many of the biologists who come to the ALS use footprinting along with the other more standard methods of crystallography and small angle scattering. We recently held a workshop at the ACA to help publicize the method and what it can be used for. Over a hundred people registered for the workshop!
Members of the ALS-ENABLE team helped organize a Bioimaging Forum to discuss current and future bioimaging methods and science at Berkeley Lab. This is the first in a series of Innovation Forums organized at the lab.
ALS-ENABLE are among a limited number of beamlines at the ALS given approval for operation during the current Bay Area shelter-in-place orders. We are open for all your research needs; but our priority at this time is to support structural biology research on the the coronavirus that causes COVID-19. If you are interested in sending… Read more