Time-Resolved SAXS Screen of Small-Molecule Drug Candidates
SIBYLS made the news for work on time-resolved, high-throughput, small-angle
x-ray scattering (SAXS) at the Advanced Light Source (ALS) improving the
screening of small-molecule drug candidates, and providing insight into how
they stimulate structural transitions in protein targets.
Publication: C.A. Brosey, T.M. Link, R. Shen, D. Moiani, K.
Burnett, G.L. Hura, D.E. Jones, and J.A. Tainer, “Chemical screening by
time-resolved X-ray scattering to discover allosteric probes,” Nat.
Chem. Biol. (2024), doi:10.1038/s41589-024-01609-1.
Read the article in ALS News here.
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