Members of the ALS-ENABLE team are working with the US Department of Agriculture on crystallizing and solving the structure of uronate dehydrogenase (UDH) variants generated using genetic engineering techniques. The overall objective of the work is to determine ways to turn agricultural waste biomass into useful chemicals. The sugar substrates for this enzyme type are a class of compounds which are left after citrus and sugar beet processing.
Initial crystallization attempts have been successful by the ALS-ENABLE team, and excellent data has been collected. Structure solution in progress!